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715951.fig.002b
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Figure 2: (a) Benign bladder mucosa (top) with diffusely infiltrating malignant cells in the lamina propria (Hematoxylin and eosin stain ×100). (b) Discohesive and loosely clustered malignant cells in an edematous stroma (Hematoxylin and eosin stain ×200). (c) The malignant cells closely resemble plasma cells with eccentric nuclei and moderate to abundant eosinophilic cytoplasms. Prominent retraction artefacts and few cells with cytoplasmic vacuoles (center) are also seen (Hematoxylin and eosin stain ×400). (d) E-Cadhedrin staining. Normally, the positivity is strong and diffuse like in the normal urothelial mucosa in the picture (bottom). It is markedly diminished in the tumor cells (upper part).