Localized Subcutaneous Acute Febrile Neutrophilic Dermatosis in a Dog
Figure 2
Histopathological images stained with hematoxylin and eosin (H&E) illustrating the histologic progression of severity analogous to the progression of macroscopic lesions. (a) Haired skin, the overview demonstrates a moderate infiltrate of neutrophils in the septa of the subcutis and extending between muscle fibers. Original magnification ×20. (b) Haired skin, epidermis and dermis: there is a perivascular to interstitial infiltrate of neutrophils (inset) in the dermis, giving the appearance of being sprinkled throughout the tissue. Original magnification ×100, inset ×400. (c) Haired skin, subcutis and muscle fibers: diffuse necrosis with disseminated karyorrhectic debris and subcutaneous thrombosis of involved vessels (inset). Original magnification ×40, inset ×400. (d) Haired skin, epidermis and dermis: the epidermis (inset) is hypereosinophilic and necrotic with severe infiltration with mainly degenerate neutrophils forming an intraepidermal pustule. The dashed line marks the border between dermis and necrotic epidermis. Original magnification ×100, inset ×400.
