ADRB2 Arg16Gly Polymorphism and Pulmonary Function Response of Inhaled Corticosteroids plus Long-Acting Beta Agonists for Asthma Treatment: A Systematic Review and Meta-Analysis

Table 1

Characteristics and methodological quality of included studies.

First author

Year

Ethnicity

Case number

Age (year)

Gender (male/female)

Main drugs and dose (μg, bid)

Follow-up (week)

Outcome measure

Genotyping measurement

HWE

NOS score

1

Qiu et al. [7]

2014

Chinese Han

68

>18

no data

FSC (250/50)

12

AM PEF and FEV1

Sequencing

Yes

7

2

Soleimani et al. [8]

2013

Iranian

28

27–65

8/18

FSC (250/50)

4

FEV1% predicted and FEV1/FVC

PCR-RFLP

Yes

6

3

Bleecker et al. [5]

2009

Mixed population

270

>12

106/194

FSC (100/50)

16

AM PEF, PM PEF, and FEV1

Tag man

—

7

4

Bleecker et al. [4]

2006

Mixed population

183

>15

81/102

FSC (100/50)

12

AM PEF, FEV1

Not mentioned

Yes

7

5

Wu et al. [9]

2015

Chinese Han

83

>5

48/35

FSC (100/25)

16

FVC, FEV1, PEF

PCR-RFLP

Yes

7