Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis

Table 1

Characteristics of studies included in the meta-analysis.

Author/year of publication	Country	Plasma cytokines assay method	Mycoplasma pneumoniae pneumonia group				Control group
			Total N	Source of pneumonia type	TNFα (pg/ml)	IFNγ (pg/ml)	Total N	Source of control	TNFα (pg/ml)	IFNγ (pg/ml)
Che et al. [23] (1)	China	Radioimmunoassay	30	MPP	497.19 ± 113.90	—	25	Healthy	161.40 ± 83.51	—
Che et al. [23] (2)	China	Radioimmunoassay	20	RMPP	520.42 ± 67.90	—	10	NRMPP	280.12 ± 26.72	—
Pan et al. [24]	China	ELISA	40	MPP	—	99.43 ± 13.18	40	Healthy	—	86.23 ± 6.31
Teng [14]	China	ELISA	44	MPP	29.22 ± 1.26	—	36	Healthy	7.98 ± 2.30	—
Qiao et al. [15]	China	ELISA	30	MPP	20.35 ± 7.63	—	20	Healthy	10.42 ± 2.64	—
Chen et al. [25]	China	ELISA	32	MPP	153.38 ± 208.34	490 ± 400	18	Healthy	38.19 ± 19.75	350 ± 150
Wang et al. [26]	China	ELISA	76	RMPP	114.5 ± 112.8	376.9 ± 296	26	NRMPP	43 ± 28	180 ± 154
He et al. [27]	China	ELISA	38	MPP	88.37 ± 14.48	—	25	Healthy	49.36 ± 16.78	—
Ye et al. [28]	China	Flow cytometry	680	MPP with acute phase	—	10.07 ± 3.18	50	Healthy	—	8.83 ± 2.03
Zhang et al. [29]	China	Flow cytometry	145	RMPP	3.0 ± 0.47	16.3 ± 6.8	489	NRMPP	2.9 ± 0.35	7.9 ± 1.27
Fan et al. [20]	China	ELISA	84	MPP	22.4 ± 0.88	12.45 ± 0.8	30	Healthy	10.71 ± 1.90	23.44 ± 4.79
Li et al. [21]	China	Flow cytometry	526	MPP	3.6 ± 22.1	20.4 ± 25.9	30	Healthy	2.2 ± 0.45	4.8 ± 1.13
Zhou and Ye [30]	China	Flow cytometry	182	MPP	2.8 ± 0.73	8.5 ± 22.0	180	Healthy	2.2 ± 0.22	4.7 ± 0.67

RMPP: refractory Mycoplasma pneumoniae pneumonia; NRMPP: nonrefractory Mycoplasma pneumoniae pneumonia.