Coronary Artery Disease: A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender

Table 5

Distribution of ADA phenotypes in relation to gender and birth weight in healthy newborns and in subjects with CAD.

BW ≤ 3000 g	Healthy newborns	CAD
Females
% of carriers of ADA*2 allele	13.7%	28.6%
total no.	95	35
Males
% of carriers of ADA*2 allele	17.2%	5.9%
total no.	87	17
Three-way contingency table analysis by a log-linear model
x = samples (healthy newborn vs CAD), y = ADA, and z = gender
x y z interaction       G    df     𝑃
4.495  1  .037
BW > 3000 g
Females
% of carriers of ADA*2 allele	16.5%	12.5%
total no.	273	23
Males
% of carriers of ADA*2 allele	15.0%	8.0%
total no.	307	50
Three-way contingency table analysis by a log-linear model
x = samples, y = ADA, and z = gender
x y z interaction   G     df    𝑃
0.205  1  .680