Coronary Artery Disease: A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender

Table 6

Birth weight in relation to ADA phenotype in healthy newborn and in subjects with CAD.

	Healthy newborns		CAD
	ADA 1/1	Carriers of ADA*2 allele	ADA 1/1	Carriers of ADA*2 allele
Females
% proportion of newborns with a BW ≤ 3000 g	26.5%	22.4%	54.3%	76.9%
total no.	310	58	46	13
Males
% proportion of newborns with a BW ≤ 3000 g	21.6%	24.6%	25.8%	20.0%
total no.	333	61	62	5
Three-way contingency table analysis by a log-linear model
x = ADA, y = BW, and z = gender
x y z interaction G   df  𝑃        G  df  𝑃
0,674      1  .4301.121  1  .320
Independence of factor z from factors x and y     2.145  3  .38019.7323  .0002