Impact of Medical Therapy on Atheroma Volume Measured by Different Cardiovascular Imaging Modalities

Table 4

Summary of trials highlighting the effects of oral hypoglycemic agents and CB1 receptor blockade on atherosclerosis. progression.

Study	N	Medication	Imaging modality	Follow-up (months)	Outcome	Result	P-value
PERISCOPE [68]	543	Pioglitazone versus Glimipride	IVUS	18	Δ PAV (%)	−0.16 versus +0.73	.002
CHICAGO [69]	462	Pioglitazone versus Glimipride	B-ultrasound	18	Δ CIMT (mm)	+0.012 versus −0.001	.02
STRADUVARIUS [67]	839	CB1-blockade (Rimonabant)	IVUS	18	Δ PAV (%)	+0.25 versus +0.51	.22
					Δ total atheroma volume (mm^3)	−2.2 versus +0.88	.03