Cardiology Research and Practice / 2010 / Article / Tab 4 / Review Article
Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention Table 4 Studies comparing acetylcysteine administration to control arm in patients undergoing coronary angiography.
Study (N) CIN definition Acetylcysteine Control
valueAzmus [77 ] (397)
25% or
0.5 mg/dL, increase in SCr at 48 hours7.1 8.4 .62 Boccalandro [81 ] ( 179)
0.5 mg/dL increase in SCr at 48 hours13 12 .84 Briguori [82 ] (183)
25% increase in Scr at 48 hours65 11 .22 Kay [79 ] (200)
25% increase in SCr at 48 hours4 12 .03 Marenzi [78 ] (354)
25% increase in SCr at 72 hours15 versus
30
.001Webb [80 ] (487)
5 mL/min decrease in CrCl23.3 20.7 .57
CIN, contrast-induced nephropathy; CrCl. Creatinine clearance; IV, intravenous; SCr, serum creatinine, dd, double dose
arm study: standard dose versus high dose versus placebo.