Cardiovascular Effects in Childhood Cancer Survivors Treated with Anthracyclines

Table 1

Characteristics and course of anthracycline-induced cardiotoxicity [15].

Characteristics	Acute cardiotoxicity	Early-onset, chronic progressive cardiotoxicity	Late-onset, chronic progressive cardiotoxicity
Onset	Within the first week of anthracycline treatment	<1 year after the completion of anthracycline treatment	≥1 year after the completion of anthracycline treatment
Risk factor dependence	Unknown	Yes^a	Yes^a
Clinical features in adults	Transient depression of myocardial contractility	Dilated cardiomyopathy	Dilated cardiomyopathy
Clinical features in children	Transient depression of myocardial contractility	Restrictive cardiomyopathy and/or dilated cardiomyopathy	Restrictive cardiomyopathy and/or dilated cardiomyopathy
Course	Usually reversible on discontinuation of anthracycline	Can be progressive	Can be progressive

From Adams et al. [15]. Reprinted with permission from John Wiley & Sons, Inc.
^aData from Giantris et al. [16], and Grenier and Lipshultz [17].