Review Article
Does Smoking Act as a Friend or Enemy of Blood Pressure? Let Release Pandora's Box
Table 3
Common classes of antihypertensive drugs and their response to smoking.
| Drug | Mechanism of action | Response to smoking |
| Beta-blockers | Inhibition beta 1 receptors | Highly reduced (+++) | ACE-Inhibitors | Blocked conversion Angiotensin 1 to Angiotensin II | Highly reduced (+++) | Calcium Antagonists | Block entry of calcium into vascular smooth cells | Reduced (++/−) | Diuretics | Decreased body sodium and extracellular fluid volume | Highly reduced (+++) | Angiotensin receptor blockers | Block AT1 receptor | not yet known (− −/+ ?) |
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+++ : strongest reduction ++/− : moderate reduction + : mild reduction − −/+ : increase ? : not yet established.
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