Acute Experimental Hyperthyroidism Does Not Affect Basal and Volume-Induced Atrial Natriuretic Peptide Secretion in Healthy Subjects

Table 3

Area under the curve differences in clinical and laboratory characteristics following normal saline-induced plasma volume expansion before and after T₃ administration in the study population.

Parameter	Δ-AUC		P value
	Before T3	After T3
Heart rate, beats per minute * hour	0.28±19	5,15±14	.457
Mean BP, mmHg * hour	−4.43±45	2.58±28.8	.668
ANP, pmol/L * hour	18.7±11.1	22.7±12.6	.212
PRA, nmol/L/h * hour	−1.67±1.42	−0.72±1.42	.122
ALDO, pmol/L * hour	−3.08±3.9	−3.08±1.36	1.000

Δ-AUC: area under the curve differences; ALDO: plasma aldosterone; ANP: plasma atrial natriuretic peptide; PRA: plasma renin activity.