Dyssynchrony Assessment with Tissue Doppler Imaging and Regional Volumetric Analysis by 3D Echocardiography Do Not Predict Long-Term Response to Cardiac Resynchronization Therapy
Table 2
Difference in left ventricular function and dyssynchrony parameters in clinical responders versus nonresponders after long-term CRT.
Variable
Clinical responders ()
Clinical nonresponders ()
P-value
Delta change 6-months after CRT
Delta change 6-months after CRT
LV end-diastolic volume (mL)
65 ± 59
12 ± 15
.03
LV end-systolic volume (mL)
74 ± 59
9 ± 10
.008
LV ejection fraction (%)
15 ± 8
3 ± 4
.001
LV end-diastolic diameter (cm)
0.5 ± 0.1
0.3 ± 0.6
.6
LV fractional shortening (%)
0.05 ± 0.1
0.05 ± 0.11
.9
TDI: Tf-Ts 6 basal segments (ms)
34 ± 34
18 ± 18
.24
TDI: Tf-Ts 12 segments (ms)
13 ± 12
13 ± 8
.96
TDI: septal-to-lateral delay (ms)
28 ± 26
54 ± 10
.07
3D: SD of Tmsv in 6 basal segments (ms)
51 ± 33
60 ± 81
.70
3D: SD of Tmsv in 12 segments (ms)
16 ± 13
28 ± 30
.16
3D: SD of Tmsv in 16 segments (ms)
34 ± 35
44 ± 35
.48
3D: SD of Tmsv in 12 segments as % of R-R interval
3.3 ± 2.9%
4.0 ± 4.3%
.60
3D: SD of Tmsv in 16 segments as % of R-R interval
4.4 ± 4.0%
3.5 ± 5.4%
.59
CRT: cardiac resynchronization therapy, LV: left ventricle, TDI: tissue Doppler imaging, Tf-Ts: difference in time to peak systolic velocity between the fastest and slowest LV segments, Tmsv: difference in longest and shortest time to minimal systolic volume in LV segments, SD: standard Deviation.
