Dyssynchrony Assessment with Tissue Doppler Imaging and Regional Volumetric Analysis by 3D Echocardiography Do Not Predict Long-Term Response to Cardiac Resynchronization Therapy
Table 3
Difference in left ventricular function and dyssynchrony parameters in echocardiographic responders versus nonresponders after long-term CRT.
Variable
Echocardiographic responders
Echocardiographic nonresponders
P-value
Delta change 6-months after CRT
Delta change 6-months after CRT
LV end-diastolic volume (mL)
71 ± 60
18 ± 26
.01
LV end-systolic volume (mL)
82 ± 58
8 ± 7
.0009
LV ejection fraction (%)
15 ± 9
6 ± 7
.01
LV end-diastolic diameter (cm)
0.7 ± 0.8
0.03 ± 0.6
.03
LV fractional shortening (%)
0.06 ± 0.1
0.03 ± 0.07
.3
TDI: Tf-Ts 6 basal segments (ms)
37 ± 34
15 ± 17
.08
TDI: Tf-Ts 12 segments (ms)
14 ± 12
10 ± 8
.36
TDI: septal-to-lateral delay (ms)
31 ± 27
41 ± 24
.43
3D: SD of Tmsv in 6 basal segments (ms)
45 ± 35
68 ± 68
.30
3D: SD of Tmsv in 12 segments (ms)
14 ± 13
27 ± 25
.13
3D: SD of Tmsv in 16 segments (ms)
35 ± 37
42 ± 33
.61
3D: SD of Tmsv in 12 segments as % of R-R interval
3.5 ± 3.0%
3.5 ± 4.0%
.97
3D: SD of Tmsv in 16 segments as % of R-R interval
3.9 ± 4.6%
4.7 ± 4.0%
.61
, CRT: cardiac resynchronization therapy, LV: left ventricle, TDI: tissue Doppler imaging, Tf-Ts: difference in time to peak systolic velocity between the fastest and slowest LV segments, Tmsv: difference in longest and shortest time to minimal systolic volume in LV segments, SD: standard Deviation.
