Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients: Role of Individual Genetic Background

Table 2

Changes in echocardiographic parameters according to ACE and βAR genotypes.

		ΔLVEF	ΔLVEDV	ΔLVESV
ACE	II versus ID, DD	7/3	−16/0*	−19/0^∗
β1AR389	≥1Arg versus GlyGly	7/−7*	16/−3*	24/−6^†
β2AR16	GlyGly versus ≥1Arg	0/6	−2/−3	−1/−5
β2AR27	GlnGln versus ≥1Glu	3/0	−3/−3	−4/−3

ΔLVEF (left ventricular ejection fraction), ΔLVEDV (left ventricular end diastolic volume), and ΔLVESV (left ventricular end systolic volume) are calculated as the percentage difference between followup and baseline left ventricular ejection fraction and volumes, respectively. Comparisons were made using the Student’s 𝑡-test for unpaired data.^∗𝑃<.05;^†𝑃<.01.