The Registry and Follow-Up of Complex Pediatric Therapies Program of Western Canada: A Mechanism for Service, Audit, and Research after Life-Saving Therapies for Young Children

Table 5

Variables found associated with outcomes of specific groups of neonates having complex cardiac surgery for congenital heart disease followed by the Complex Pediatric Therapies Follow-up Program.*

Group (years, n)	Associated with survival	Associated with MDI	Associated with PDI
ASO (1996–2004; 𝑛=88) [54]	—	EGA, preoperative lactate and days ventilated, days in hospital
ASO (1996–2003; 𝑛=65; 5-year outcomes of FSIQ) [55]	—	Mother’s years of schooling, EGA, postoperative d1 lactate
TAPVC (1996–2004; 𝑛=32) [60]	—	SES	Weight at surgery, postoperative d1 lactate
Norwood MBTS (1996–2002; 𝑛=62) [58]	Postoperative d2-5 lactate and base deficit	SES, hospital days	Sex
Norwood RVPA (2002–2005; 𝑛=32) [58]	Postoperative d2-5 lactate	Preoperative Pa02 and days ventilated, DHCA time	CPR anytime, hospital days
Norwood (1996–2005, no ECLS, 𝑛=82) [62]	Postoperative d2-5 nadir haemoglobin level	First postoperative day of negative fluid balance	Sex, first postoperative day of negative fluid balance
IAA (1996–2006; 𝑛=27) [66]	—	Chromosomal abnormality, Apgar score, DHCA used	Chromosomal abnormality
Cardiac ECLS (2002–2004; 𝑛=39) [63]	Single ventricle, lactate on admission, days ventilated	Chromosomal abnormality, time for lactate to fall on ECLS, highest inotrope score first 5d on ECLS	—
Heart transplant (1999–2006; 𝑛=33) [67]	Congenital heart disease	Congenital heart disease	Congenital heart disease

ASO: arterial switch operation for transposition of the great arteries; TAPVC: total anomalous pulmonary venous correction; MBTS: modified Blalock-Taussig shunt; RVPA: right ventricle-to-pulmonary artery shunt; IAA: correction of interrupted aortic arch; ECLS: extracorporeal life support; E-CPR: ECLS started during ongoing chest compressions for refractory cardiac arrest; EGA: early gestational age; MDI: Mental Developmental Index; PDI: Psychomotor Developmental Index; *Variables that are potentially modifiable are in italicized font.