Genetic Insights into Bicuspid Aortic Valve Formation
Figure 1
Schematic representation of a bicuspid aortic valve. (a) Transverse section through the aorta showing a normal aortic valve with three leaflets and their corresponding points of attachment to the aortic wall. A bicuspid aortic valve arises from fusion of two different cusps, resulting in the formation of a conjoined leaflet. (b) Schematic representation of the BAV subtypes. The R-N BAV arises from fusion of the right coronary cusp and noncoronary cusp whereas the R-L BAV results from the fusion of the right coronary cusp and left coronary cusp. LCA: left coronary artery; LCC: left coronary cusp; NCC: noncoronary cusp; RCA: right coronary artery; RCC: right coronary cusp.
