Review Article

Potential of Novel EPO Derivatives in Limb Ischemia

Table 1

Recent studies investigating the role of nonhaematopoietic derivatives of EPO.

AuthorNonhaematopoietic EPO derivativeModelInference

Erbayraktar et al. 2003 [10]Asialo EPOIn vivo model of cerebral and spinal cord ischaemia plus sciatic nerve injuryNeuroprotection-recovery of paraplegia
Leis et al. 2004 [11]Carbamylated EPO (CEPO)In vitro and in vivo models of neural injuryDemonstration of tissue protective properties of CEPO in neural tissue
Fiordaliso et al. 2005 [12]CEPOIn vivo model of rat myocardial infarctionReduction in the size of myocardial infarct
Fantacci et al. 2006 [13]CEPOIn vivo model of metabolic stress in mice induced by chronic hypoxia (CH)CEPO reduced metabolic stress caused by CH and improved cellular survival independent of haematopoiesis.
Erbayraktar et al. 2006 [14]CEPOIn vivo model of radiosurgically induced brain injury in ratsDecreased necrosis of the brain tissue
Erbayraktar et al. 2009 [15]CEPO and ARA 290In vivo models of decubitus ulcers and peritonitisImproved healing and less intraperitoneal adhesion formation
Ahmet et al. 2010 [16]ARA 290In vivo model of myocardial ischemiaReduction in the size of infarct and improvement of ejection fraction
Joshi et al. 2010 [17]ARA 290In vitroDecreased apoptosis of myotubes but no effect on angiogenesis
Joshi et al. 2011 [18]ARA 290In vitroDecreased ischaemia-induced inflammation and apoptosis of myotubes