Table 2: Summary of antiplatelet/anticoagulation requirements and endocarditis prophylaxis for each percutaneous device.

AspirinClopidogrelWarfarinEndocarditis Prophylaxis

AMPLATZER septal occluder [28]Few months indefinitely depending on treating centreNone, few months depending on treating centreNone, 6 weeks depending on treating centreFew months

PLAATO [30]300–325 mg daily indefinitely75 mg for 6 months at North American centres and at operator’s discretion at European centresNil6 months at North American centres and at operator’s discretion at European centres

WATCHMAN [33]81–325 mg daily indefinitely75 mg for 6 monthsAt least 45 days. Discontinued at 45 days if follow up TEE shows <5 mm of peridevice flowNil

AMPLATZER cardiac plug [35]Not specifiedNot specifiedNot specifiedNot specified

Coherex Wave Crest75–325 mg daily indefinitely75 mg daily for 90 days if not on warfarinIf previously on warfarin with a history of stroke or TIA, continue warfarin until LAA closure demonstrated on TEENil

LARIATIndefinitelyNilIf previous embolic events whilst on OAC and no contraindication or intolerance, OAC continued regardless of procedural successNil

TIA: transient ischaemic attack and OAC: oral anticoagulant.