Protective Function of STAT3 in CVB3-Induced Myocarditis

Figure 5

Collagen expression and expression of the ECM degrading system in cardiac tissue of CVB3-infected mice. The area fractions of collagen I and collagen III are shown 10 and 28 days after CVB3 infection of WT and STAT3 KO mice as x-fold compared to the corresponding untreated controls. The mRNA expression data of MMP13 and TIMP1 are normalized to the house-keeping gene 18S and to the expression levels of the corresponding untreated mice and expressed as x-fold over basal expression using the formula 2^−ΔΔCt. The ratios were calculated without previous normalization to the untreated controls. * Data were compared to the expression of the corresponding untreated controls. *𝑃<0.05; **𝑃<0.01; ***𝑃<0.001. ^§Data between WT and STAT3 KO mice were compared. ^§𝑃<0.05; ^§§𝑃<0.01. ^#Data between 10 or 28 days were compared. ^#𝑃<0.05.

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