Research Article

Protective Function of STAT3 in CVB3-Induced Myocarditis

Table 1

Animal characteristics and hemodynamic measurements 28 days after CVB3 infection.

WTWT-CVB3STAT3 KOSTAT3 KO-CVB3

Body weight [g] 2 9 ± 2 2 3 ± 1 2 8 ± 1 2 2 ± 1
Heart weight [g] 0 . 1 5 ± 0 . 0 3 0 . 0 9 ± 0 . 0 1 0 . 1 1 ± 0 . 0 1 0 . 0 9 ± 0 . 0 1
Global function
 Heart rate [bpm] 4 3 4 ± 3 0 4 0 4 ± 1 4 3 5 3 ± 9 0 4 2 0 ± 1 2
 Cardiac output [mL/min] 1 5 ± 1 1 1 ± 1 * 1 4 ± 1 8 ± 1 *†
 Stroke volume [μL] 3 1 ± 4 2 9 ± 2 3 0 ± 1 2 2 ± 2
 Stroke work [μL · mmHg] 3 5 8 9 ± 1 1 6 2 3 8 4 ± 1 1 7 ** 3 3 3 1 ± 1 7 3 1 6 3 1 ± 1 2 5 *††
 Ejection fraction [%] 6 7 ± 3 5 2 ± 2 6 8 ± 2 3 9 ± 2 **††
Systolic function
 Pes [mmHg] 1 2 3 ± 6 1 0 0 ± 1 * 1 2 2 ± 1 1 7 4 ± 9 *†
d P / d t m a x [mmHg/s] 9 6 4 0 ± 7 8 6 6 6 6 3 ± 3 2 5 * 9 4 1 5 ± 6 3 7 3 4 2 2 ± 2 0 2 **††
 Ves [μL] 2 8 ± 2 3 1 ± 3 2 6 ± 2 4 7 ± 5 *†
Diastolic function
 Ped [mmHg] 4 . 0 ± 0 . 8 1 1 . 0 ± 1 . 2 * 3 . 7 ± 0 . 3 1 8 . 7 ± 3 . 0 *†
d P / d t m i n [mmHg/s] 7 8 7 3 ± 3 1 9 4 7 5 7 ± 2 4 0 ** 7 8 1 3 ± 1 3 1 2 8 1 8 ± 2 1 6 **††
 Tau [ms] 1 1 . 7 ± 0 . 3 1 5 . 2 ± 0 . 4 * 1 1 . 3 ± 0 . 7 1 7 . 8 ± 0 . 8 **†
 Ved [μL] 4 9 ± 5 5 7 ± 3 4 8 ± 3 7 4 ± 4 **††

*Significantly different versus respective control.
Significantly different versus WT-CVB3.