Fetal Intervention in Right Outflow Tract Obstructive Disease: Selection of Candidates and Results

Table 1

Criteria used for prenatal echocardiographic prediction of postnatal outcome for pulmonary atresia/critical pulmonary stenosis with intact ventricular septum (PA/CS-IVS).

Reference	Prenatal predictors of non-BV outcome	Test accuracy
Salvin et al. (2006) [22]	(i) TV 𝑧-score ≤ -3	Sn 92%, Sp 100%
Roman et al. (2007) [19]	(i) TV/MV ratio < 0.7	3/4 criteria: Sn 100%, Sp 75%
	(ii) RV/LV length ratio < 0.6
	(iii) Tricuspid inflow duration/cardiac cycle length ≤ 31.5%
	(iv) Presence of ventriculocoronary connections
Gardiner et al. (2008) [12]	(i) PV 𝑧-score < −1 or TV 𝑧-score < −3.4 before 23 weeks	(i) 2/2 criteria < 23 weeks: Sn 100%, Sp 80%
	(ii) Median TV 𝑧-score < −3.95, before 26 weeks	(ii) 1 criteria < 26 weeks^*: Sn 92%, Sp 100%
	(iii) Median PV 𝑧-score < −2.8 and medium TV/MV ratio < 0.7 at 26–31 weeks	(iii) 2/2 criteria at 26–31 weeks: Sn 100%, Sp 100%
	(iv) Median TV 𝑧-score < −3.9 and medium TV/MV ratio < 0.59 after 31 weeks	(iv) 1 criteria after 31 weeks: Sn 100%, Sp 100%
Gómez-Montes et al. (2011) [17]	(i) TV/MV ratio ≤ 0.83
	(ii) RV/LV length ratio ≤ 0.64	4/4 criteria: Sn 100%, Sp 100%
	(iii) PV/AV ratio ≤ 0.75	3/4 criteria: Sn 100%, Sp 92%
	(iv) Tricuspid inflow duration/cardiac cycle length ≤ 36.5%

TV: tricuspid valve; MV: mitral valve; RV: right ventricle; LV: left ventricle; PV: pulmonary valve; AV: aortic valve; BV: biventricular; Sn: sensitivity; Sp: specificity.
^*In combination with hemodynamical markers of right atrial pressure (severity of tricuspid regurgitation, waveform characteristics of the ductus venosus, and restriction of the interatrial septum) and the presence of coronary artery fistulae.