Molecular pathways affected by n-3 PUFA [9]. AA: arachidonic acid; COX: cyclooxogenase; cPLA₂: cytosolic phospholipase A₂; CYP450: cytochrome P450; DHA: docosahexaenoic acid; DNA: deoxyribonucleic acid; ERK: extracellular signal-regulated kinase; GPR 120: G-protein-coupled receptor 120; HNF: hepatic nuclear factor; LOX: lipoxygenase; mRNA: messenger ribonucleic acid; n-3 FA: n-3 fatty acids; NF-κB: nuclear factor-kappaB; PGE2: prostaglandin E2; PMN: polymorphonuclear leukocyte; PPAR: peroxisome proliferator-activated receptor; RXR: retinoid X receptor; SREBP-1c: sterol regulatory element binding protein-1c.