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Cardiology Research and Practice
Volume 2012 (2012), Article ID 754181, 9 pages
http://dx.doi.org/10.1155/2012/754181
Clinical Study

Eicosapentaenoic Acid Supplementation Changes Fatty Acid Composition and Corrects Endothelial Dysfunction in Hyperlipidemic Patients

1Second Department of Internal Medicine, Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, University of the Ryukyus Graduate School of Medicine, Okinawa 903-0215, Japan
2Diabetes and Life-Style Related Disease Center, Tomishiro Chuo Hospital, Okinawa 901-0243, Japan
3Department of Cardio-Diabetes Medicine, The University of Tokushima Graduate School of Health Biosciences, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
4Cardiovascular Division, Naha City Hospital, Okinawa 902-8511, Japan
5Cardiovascular Division, Tomishiro Chuo Hospital, Okinawa 901-0243, Japan
6Cardiovascular Division, Shonan Hospital, Okinawa 904-0034, Japan
7Heart Center, Wajiro Hospital, Fukuoka 811-0213, Japan
8Department of Clinical Pharmacology and Therapeutics, University of the Ryukyus Graduate School of Medicine, Okinawa 903-0215, Japan
9Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, 3-18-15 Kuramoto, Tokushima 770-8503, Japan

Received 31 July 2012; Accepted 11 September 2012

Academic Editor: Chim Choy Lang

Copyright © 2012 Ken Yamakawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure: Ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA) (left panel) and peak forearm blood flow during reactive hyperemia (right panel) at baseline and at 3 months after EPA supplementation in hyperlipidemic subjects (n = 16).

  1. Supplementary Figure