Genomic Research to Identify Novel Pathways in the Development of Abdominal Aortic Aneurysm

Table 2

SNPs associated with AAA after meta-analysis of candidate gene studies [25, 26].

Gene/polymorphism	Number of studies (total cases/controls)	Effect size (OR and 95% CI)
Angiotensin type 1 Receptor/A116C (rs5186)	1 study, 3 populations (1226/1712)	1.386 (1.2–1.601)
Angiotensin converting Enzyme I/D (rs4646994)	4 (1657/2238)	1.238 (1.12–1.36)
Methlyenetetrahydrofolate reductase +677C>T	5 (1086/895)	1.234 (1.020–1.494)
Matrix metalloproteinase 9 (MMP9, 1562C>T)	3 (848/802)	1.09 (1.01–1.18)