Metabolic Syndrome Derived from Principal Component Analysis and Incident Cardiovascular Events: The Multi Ethnic Study of Atherosclerosis (MESA) and Health, Aging, and Body Composition (Health ABC)

Table 4

Cox proportional hazard models illustrating the association of NCEP and binary MetS-PC MetS definitions with CVD events in the MESA cohort.

All cardiovascular events (𝑛=377)
	All CVD	NCEP MetS			MetS-PC MetS
	HR	95% CI	𝑃 value	𝜒^2 value	HR	95% CI	𝑃 value	𝜒^2 value
Model 1
Overall	1.87	1.53, 2.28	0.0001	37	2.14	1.75, 2.62	0.0001	55
Caucasian	1.99	1.47, 2.71	0.0001	19	1.97	1.45, 2.68	0.0001	19
Chinese	1.49	0.72, 3.10	0.28	1	1.61	0.78, 3.35	0.19	2
African	1.74	1.18, 2.54	0.005	8	2.21	1.50, 3.27	0.0001	16
Hispanic	1.99	1.28, 3.11	0.002	9	2.88	1.81, 4.60	0.0001	20
Model 2
Overall	1.78	1.45, 2.18	0.0001	31	2.32	1.89, 2.84	0.0001	66
Caucasian	1.85	1.36, 2.52	0.0001	15	1.98	1.45, 2.69	0.0001	19
Chinese	1.42	0.68, 2.99	0.35	1	1.71	0.82, 3.57	0.15	2
African	1.73	1.18, 2.55	0.005	8	2.66	1.79, 3.94	0.0001	24
Hispanic	1.86	1.19, 2.91	0.007	7	3.10	1.94, 4.96	0.0001	22
Model 3
Overall	1.79	1.46, 2.20	0.0001	31	2.34	1.91, 2.87	0.0001	67
Caucasian	1.84	1.35, 2.51	0.0001	15	1.95	1.43, 2.67	0.0001	18
Chinese	1.50	0.71, 3.17	0.28	1	1.80	0.86, 3.77	0.12	2
African	1.75	1.19, 2.57	0.004	8	2.68	1.81, 3.98	0.0001	24
Hispanic	1.92	1.22, 3.03	0.005	8	3.38	2.09, 5.44	0.0001	25

Model 1, univariate analysis; model 2, adjusted for age and gender; model 3, model 2, plus cigarette smoking and low-density lipoprotein; the overall hazards were further adjusted for race/ethnicity in models 2 and 3; CVD, cardiovascular disease; NCEP MetS (binary variables); MetS-PC (binary variables, with the cut point being 0.475); HR hazards ratio.