Review Article

Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon?

Table 2

Characteristics of platelet function assays [122].

Assay LTAMEAVerifyNow P2Y12VASPImpact-RPFA 100 INNOVANCEPlatelet works

Measurement AggregationAggregationAggregationActivationAdhesion/aggregationAggregationAggregation
Specimen type Platelet-rich plasmaWhole bloodWhole bloodWhole bloodWhole bloodWhole bloodWhole blood
Standard conditions Variable ADP concentrationVariable ADP concentrationFixed ADP and PGE1Fixed ADP and PGE1Recommended ADPFixed PGE1Recommended ADP
Technical skills required Specialized lab and personnelSpecialized lab and personnelNoneSpecialized lab and personnelSpecialized lab and personnelNoneNone
AdvantagesWell-studied tied to clinical outcomesPhysiologic environment
Minimal sample manipulation
User-friendly and fast No sample processingP2Y12 receptor-specific
Small blood volume required
User-friendly and fast
Small blood volume required
User-friendly and fast
Small blood volume required
Fast
DisadvantagesTime and extent of processing lack of standardizationLess clinical evidence with assay smaller range for responseUnadjustable agonist concentration expensiveMeasures earlier marker (signaling) Limited experience with assayResult dependent on von Willebrand factor levels and hematocritTime dependent
Not well studied