High-Sensitivity Troponin T: A Biomarker for Diuretic Response in Decompensated Heart Failure Patients

Table 5

Determinants of hsTnT dichotomic changes.

	hsTnT		value
	Decrease	Increase
Age (years)	75,94 ± 11,92	76,11 ± 8,97	0,940
Male sex—no. (%)	22 (34,9)	17 (45,9)	0,275**
DM—no. (%)	24 (38,1)	21 (56,8)	0,070**
HGA1c (%)	6,93 ± 0,94	7,13 ± 1,00	0,475
Sleep apnea—no. (%)	7 (36,8)	11 (44)	0,632**
NIV—no. (%)	10 (15,9)	7 (18,9)	0,695**
IHD—no. (%)	32 (50,8)	18 (48,6)	0,836**
AF—no. (%)	31 (49,2)	28 (75,7)	0,009 **
LVEF (%)	43,37 ± 12,68	43,62 ± 10,08	0,917
LVEF ≥40%—no. (%)	41 (65,1)	26 (70,3)	0,594**
HgB (g/dL)	12,32 ± 1,95	12,62 ± 2,28	0,478
Albumin (mg/dL)	3,68 ± 0,41	3,67 ± 0,39	0,924
ΔBMI (Kg/m^2)	−1,08 ± 1,70	−1,10 ± 1,76	0,964
ΔHR (bpm)	−17,05 ± 20,71	−17,57 ± 29,15	0,917
ΔSBP (mmHg)	−18,56 ± 23,32	−16,57 ± 27,63	0,702
ΔpCr (mg/dL)	0,03 [−0,1 to 0,18]	0,02 [−0,06 to 0,11]	0,803*
ΔeGFR (mL/min/1,73 m^2)	−2,0 [−9,0 to 7,0]	−1,0 [−11,0 to 6,0]	0,937*
ΔpUrea (mg/dL)	7,40 ± 20,59	6,59 ± 20,65	0,851
ΔNTproBNP (pg/mL)	−1167 [−2337 to −367]	−379 [−1273 to 319,5]	0,003 *
ΔhsTnT (ng/mL)	−0,004 [−0,014 to −0,001]	0,004 [0,002 to 0,009]	<0,001 *
ΔAlbuminuria (mg/g)	−6,10 [−38,50 to 2,40]	−23,70 [−90,75 to 11,05]	0,337*
IV furosemide at day 1 (mg)	78,83 ± 21,61	74,05 ± 21,53	0,537
IV furosemide dose
Maintenance or increase at day 3—no. (%)	9 (14,3)	7 (18,9)	0,542**
ACEi—no. (%)	30 (47,6)	14 (37,8)	0,341**
Beta-blocker—no (%)	22 (34,9)	15 (40,5)	0,574**
Spironolactone—no. (%)	30 (47,6)	20 (54,1)	0,534**
Length of stay (days)	8,0 [6,0 to 11,0]	9,0 [7,0 to 12,0]	0,033 *

Continuous variables are presented as mean value ± standard deviation SD, value or median [interquartile range (IQR)], value. Categorical variables are presented as absolute number (%), value.
*Nonparametric paired sample test; **chi-square test.
DM: diabetes mellitus; HgBA1c: glycated hemoglobin; NIV: noninvasive ventilation; IHD: ischemic heart disease; AF: atrial fibrillation; HgB: hemoglobin; BMI: body mass index; HR: heart rate; SBP: systolic blood pressure; eGFR: estimated glomerular filtration rate; pCr: plasma creatinine; pUrea: plasma urea; NTproBNP: N-terminal probrain natriuretic peptide; hsTnT: high sensitivity troponin T; IV: intravenous; ACEi: angiotensin converting enzyme inhibitors; Δ: changes between day 3 and day 1 (day 3–day 1).