Neutralization by Insulin of the Hypertensive Effect of Dermcidin Isoform 2: An Environmentally Induced Diabetogenic and Hypertensive Protein

Figure 2

The in vivo effect of dermcidin on the blood glucose and plasma insulin levels in mice. Normal adult mice were injected with 0.2 μM purified dermcidin in the tail vein and their blood glucose, plasma insulin, and NO levels were recorded at different times as shown. Solid squares (■) represent the blood glucose level in these animals at different times. Solid circles (●) demonstrate the insulin level at different times. Hollow squares (□) represent the corresponding NO level at different times as indicated. The figure represents data expressed in mean ± SD of 10 different experiments using 6 different animals, each in triplicate.