The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics

Figure 1

The genetic and nongenetic factors which may contribute to clopidogrel variable platelets reactivity. The figure presents the known genetic and nongenetic factors (cellular and clinical factors) which may contribute to clopidogrel variable platelets reactivity. CYP: cytochrome P450, ADP: adenosine diphosphate, GPIIB/IIIa: Glycoprotein IIB/IIIa, ABCB1: ATP-Binding Cassette Subfamily B Member 1. This figure is adapted and modified with permission from the publisher. Original source: Angiolillo and Ferreiro (2010) [85]. Copyright© (2010) Sociedad Española de Cardiología. Published by Elsevier España SL. All rights reserved.