Echo- and B-Type Natriuretic Peptide-Guided Follow-Up versus Symptom-Guided Follow-Up: Comparison of the Outcome in Ambulatory Heart Failure Patients

Table 2

Univariate and multivariate predictors of all-cause mortality among 224 patients of the BNP- and echo-guided group.

Variable	Univariate		Multivariate
	HR (95% CI)	-value	HR (95% CI)	-value
Age	1.03 (1.00, 1.05)	0.043
Male	0.98 (0.51, 1.97)	0.98
Heart rate	1.01 (1.00, 1.03)	0.11
Ischemic CM	1.23 (0.88, 1.72)	0.29
Diabetes	1.98 (1.13, 3.45)	0.021
Hypertension	0.97 (0.55, 1.73)	0.93
Atrial fibrillation	1.39 (0.68, 2.85)	0.38
NYHA class	2.38 (1.67, 3.38)	<0.0001
Systolic BP	0.97 (0.95, 0.99)	0.0022
Diastolic BP	0.96 (0.93, 0.99)	0.0032
eGFR	0.98 (0.97, 0.99)	0.0040
BNP	1.00 (1.00, 1.00)	<0.0001
BNP >125 pg/ml or decrease ≤30%	5.74 (2.97, 11.07)	<0.0001	1.55 (1.35, 1.77)	0.0038
LVEF	0.89 (0.85, 0.92)	<0.0001	0.94 (0.89, 1.00)	0.051
Mitral regurgitation	3.58 (3.00, 6.38)	<0.0001
EDT	0.99 (0.98, 0.99)	<0.0001
E/e′ averaged	1.06 (1.04, 1.08)	<0.0001	1.05 (1.02, 1.08)	0.0054
B-lines ≥ 15	7.32 (4.13, 12.96)	<0.0001

HR: hazard ratio. For other abbreviations, see Table 1.