Echo- and B-Type Natriuretic Peptide-Guided Follow-Up versus Symptom-Guided Follow-Up: Comparison of the Outcome in Ambulatory Heart Failure Patients

Table 3

Univariate and multivariate predictors of the combined end point among 224 patients of the BNP- and echo-guided group.

Variable	Univariate		Multivariate
	HR (95% CI)	-value	HR (95% CI)	-value
Age	1.03 (1.00, 1.05)	0.071
Male	0.56 (0.24, 1.37)	0.56
Heart rate	1.02 (1.01, 1.04)	0.026
Ischemic CM	1.14 (0.67, 1.94)	0.64
Diabetes	3.14 (1.44, 6.80)	0.0057
Hypertension	1.41 (0.62, 3.23)	0.42
Atrial fibrillation	1.62 (0.8, 4.55)	0.38
NYHA class	2.29 (1.37, 3.84)	0.0016
Systolic BP	0.98 (0.96, 1.00)	0.14
Diastolic BP	0.95 (0.91, 0.99)	0.0079
eGFR	0.98 (0.96, 0.99)	0.0073
BNP	1.00 (1.00, 1.00)	0.0033
BNP >125 pg/ml or decrease ≤30%	8.52 (2.89, 25.16)	<0.0001	2.48 (1.14, 5.42)	0.023
LVEF	0.88 (0.84, 0.94)	<0.0001	0.95 (0.91, 1.00)	0.052
Mitral regurgitation	3.58 (3.00, 6.38)	<0.0001
EDT	0.98 (0.97, 0.99)	<0.0001
E/e′ averaged	1.06 (1.04, 1.09)	<0.0001
B-lines ≥ 15	5.64 (2.47, 12.83)	<0.0001	2.62 (1.26, 5.42)	0.0099

For abbreviations, see Table 2.