Preoperative Low-Molecular-Weight Heparin Prophylaxis Associated with Increased Heparin Resistance Frequency in On-Pump Coronary Artery Bypass Graft Surgery

Table 1

Patient demographics, clinical characteristics, and operative data.

	HR− ()		HR+ ()		P value
	Group 1 LMWH− ()	Group 3 LMWH+ ()	Group 2 LMWH− ()	Group 4 LMWH+ ()
Age (y)	66 ± 10	63 ± 9	63 ± 11	65 ± 11	0.463
Gender (F) (n)	22	20	2	6	0.658
Weight (kg)	77 ± 12	80 ± 12	77 ± 7	80 ± 16	0.598
Preoperative platelet count (×1000 μL)	249 ± 74	275 ± 85	168 ± 70	197 ± 75	<0.001
Intraoperative patients’ data
CPB time (min)	67.8 ± 26.0		94.2 ± 55.9		0.033^α
Aortic clamp time (min)	45.5 ± 17.9		51.52 ± 18.7		0.022^α
Basal ACT (sec)	126 ± 16	125 ± 15	119 ± 18	122 ± 15	0.654
Postheparin ACT (sec)	633.58 ± 205.1		450.69 ± 133.2		0.001^α
Postprotamine ACT (sec)	133 ± 22	154 ± 7	128 ± 19	133 ± 25	0.034+
Intraoperative FFP used (units)	2.1 ± 0.9	3.8 ± 1.8	2.1 ± 0.9	4.5 ± 1.8	<0.001^x
Intraoperative thrombocyte used (units)	0.3 ± 1.3	1.0 ± 2.2	0.3 ± 1.5	2.2 ± 3.1	0.001^x
Reexploration (n)	0	0	0	2	0.980
Mortality (n)	1	0	0	4	0.013^y

Data are presented as mean ± SD. LMWH, low-molecular-weight heparin; HR, heparin resistance; n, number; y, years; F, female; kg, kilograms; CPB, cardiopulmonary bypass; min, minutes; ACT, active coagulation time; sec, seconds; FFP, fresh frozen plasma. Significant difference was between Groups 2 and 3. ^αSignificant difference was between groups HR+ and HR−. ^xSignificant difference was between Groups 1 and 4 and Groups 2 and 4. ^ySignificant difference was between Groups 2 and 4 and Groups 3 and 4.