Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis

Figure 3

TSA calculated to reliably detect a 25% relative change in the incidence of death from any cause, assuming a control group event rate of 8.99% with a power of 80% at an alpha of 5%. Notes: DARIS: diversity adjusted required information size; Pc: event proportion in the control group; RRR: relative risk reduction in the intervention group; (a) type I error; (b) type II error; DIVERSITY: diversity (D-square). Dead: the required information size was 5,187 participants. The cumulative Z-score (blue line) did not cross the trial sequential monitoring boundaries for benefit (red lighter inward sloping line) after the seven trials.