Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis

Figure 5

TSA calculated to reliably detect a 25% relative change in the incidence of infection from any cause, assuming a control group event rate of 24.6% with a power of 80% at an alpha of 5%. Notes: DARIS: diversity adjusted required information size; Pc: event proportion in the control group; RRR: relative risk reduction in the intervention group; (a) type I error; (b) type II error; DIVERSITY: diversity (D-square). Infection: the required information size was 1,315 participants. The cumulative Z-score (blue line) crossed the trial sequential monitoring boundaries for benefit (red lighter inward sloping line) after the second trial (1,090 participants); thus, the risk of random error in the finding can be excluded. Therefore, it is not necessarily additional testing based on the assumed intervention effect of the RRR of 25%, an alpha of 5%, and a beta of 20% with respect to this result.