Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography

Table 4

Stress echocardiography after 30 days of therapy (T2).

	IG pts		CG pts
	T2		T2		value
	Rest	Peak exercise	Rest	Peak exercise	Rest	Peak exercise
Mean heart rate (bpm)	63.6 ± 4.2	132.3 ± 13.2	63.7 ± 10.5	120.4 ± 15	0.97	0.03
Max HR (bpm)	79.3 ± 7.1		71.1 ± 10.9		0.02
Chronotropic reserve (bpm)	68.7 ± 14		0.0007		48.7 ± 14
Systolic blood pressure (mmHg)	122.8 ± 8	182.9 ± 8	120.7 ± 13	179.3 ± 20	0.6	0, 5
Exercise time	9′:49″±48″		8′:09″±59″		0.0001
METs	10.4 ± 0.7		9.3 ± 0.6		0.0001
Maximal test (%)	30%		14%		0.06
DP	24194 ± 2697		20358 ± 4671.8		0.01
ΔDP	16.4 ± 2.8		12.6 ± 3.5		0.003
Peak power (Watt)	139.3 ± 13.4		118.7 ± 19.6		0.003
Symptoms (%)	7		42.8		0.07
ECG alterations (%)	14.2		57.1		0.046
Mean rest LVEF (%)	53.6 ± 2.2		50.4 ± 6.1		0.07
LVEDD (mm)	47.1 ± 2.3	46 ± 2.5	50.3 ± 4.0	49.4 ± 3.6	0.01	0.07
LVEDV (ml)	129.7 ± 21.0	122.7 ± 18.5	128.4 ± 42.3	116 ± 34.9	0.15	0.53
LVESV (ml)	60.3 ± 10.2	55.9 ± 8.8	65.7 ± 30.3	57.6 ± 23.6	0.53	0.8
E wave (cm/sec)	65.0 ± 7.4	84 ± 7.9	70.9 ± 20.3	97.1 ± 29.6	0.31	0.12
A wave (cm/sec)	61.7 ± 14.2	80.4 ± 20.6	74.6 ± 11.9	91.1 ± 9.2	0.01	0.08
E/A	1.10 ± 0.3	1.14 ± 0.5	0.96 ± 0.3	1.06 ± 0.3	0.22	0.61
E′ wave (cm/sec)	7.4 ± 1.7	10.6 ± 1.9	7.1 ± 1.6	9.6 ± 2.4	0.6	0.2
E/E′	9.2 ± 2.7	7.9 ± 1.6	10.0 ± 2.4	10.2 ± 2.0	0.4	0.002
ΔE′	3.14 ± 0.7		2.4 ± 1.13		0.047
ET corrected for HR (sec)	0.43 ± 0.04	0.76 ± 0.10	0.43 ± 0.90	0.58 ± 0.10	1	0.0001
DT corrected for HR (sec)	0.51 ± 0.05	0.78 ± 0.09	0.59 ± 0.09	0.76 ± 0.16	0.007	0.7
TP	17239 ± 4710		12206 ± 4413		0.007
ΔTP	4785 ± 671		3359 ± 941		0.0001

DP = double product; TP = triple product; LVEF = left ventricular ejection fraction; LVEDD = left ventricular end-diastolic diameter; ET = ejection time; DT = diastolic time.