Targeted Disruption of Calcium/NFAT Signaling Reveals a Left-Right Determination Disorder in the Pharyngeal Arch Artery
Figure 1
Right aortic arch formed after administration of FK506. (a) A photograph of a normal fetus at E13.5. The arrow indicates the normal aortic arch that runs toward the left-hand side. The dotted line arrow indicates the normal ductus arteriosus. The asterisk indicates the brachiocephalic trunk. (b) A photograph of an FK506-treated fetus at E13.5. The arrow indicates the right aortic arch, which runs toward the back of the right-hand side (*). The dotted line arrow indicates the ductus arteriosus running to the right. Asterisks (**) indicate the arteria subclavia sinistra. (c) An HE-stained section of dorsal artery in a normal fetus. The white dotted line indicates the positions of the pharynx and esophagus, and the asterisk indicates the oropharynx. The arrow indicates the dorsal artery located on the left-hand side of the white dotted line. (d) An HE-stained section of the dorsal artery in an FK506-treated fetus. The asterisk and the white dotted line indicate the same as that in (c). The arrow indicates the dorsal artery located on the right-hand side of the white dotted line.
