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Discrete Dynamics in Nature and Society
VolumeΒ 2008Β (2008), Article IDΒ 746951, 13 pages
http://dx.doi.org/10.1155/2008/746951
Research Article

A Delayed Epidemic Model with Pulse Vaccination

1Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, China
2School of Sciences, Jimei University, Xiamen 361021, China

Received 14 November 2007; Revised 7 January 2008; Accepted 18 February 2008

Academic Editor: LeonidΒ Berezansky

Copyright Β© 2008 Chunjin Wei and Lansun Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A delayed SEIRS epidemic model with pulse vaccination and nonlinear incidence rate is proposed. We analyze the dynamical behaviors of this model and point out that there exists an infection-free periodic solution which is globally attractive if 𝑅1<1, 𝑅2>1, and the disease is permanent. Our results indicate that a short period of pulse or a large pulse vaccination rate is the sufficient condition for the eradication of the disease. The main feature of this paper is to introduce time delay and impulse into SEIRS model and give pulse vaccination strategies.

1. Introduction

Infectious diseases are usually caused by pathogenic microorganisms, such as bacteria, viruses, parasites, or fungi; the diseases can be spread directly or indirectly. The severe and sudden epidemics of infectious diseases have a great influence on the human life and socioeconomy, which compel scientists to design and implement more effective control and preparedness pro- grams. Pulse vaccination is an effective method to use in attempts to control infectious diseases.

In recent years, epidemic mathematical models of ordinary differential equations have been studied by many authors (e.g., [1–3]). In most of the research literatures, authors always assume that the disease incubation is negligible, therefore, once infected, each susceptible in- dividual becomes infectious instantaneously and later recovers with a temporary acquired im- munity. An epidemic model based on these assumptions is customarily called SIR (susceptible, infectious, recovered) model. However, many diseases incubate inside the hosts for a period of time before the hosts become infectious. We assume that a susceptible individual first goes through a latent period after infection before becoming infectious. The resulting model is called SEIRS (susceptible, exposed, infectious, recovered) model. The SEIRS infections disease model is a very important biologic model and has been studied by many authors (e.g., [4–6]).

Bilinear and standard incidence rates have been frequently used in classical epidemic models [7]. Simple dynamics of these models seem related to such functions. These different incidence rates have been proposed by researchers. Anderson et al. pointed out that standard incidence is more suitable than bilinear incidence [8–10]. Levin et al. have adopted an incidence form like π›½π‘†π‘žπΌπ‘ or π›½π‘†π‘žπΌπ‘/𝑁 which depends on different infective disease and environments [11]. L. S. Chen and J. Chen [12] set forth transmission effect like the saturation effect 𝛽𝑆(𝑑)/(1+π‘Žπ‘†(𝑑)) as the infection rate. In this paper, we will adopt the infection rate 𝛽𝑆(𝑑)/(1+π‘Žπ‘†(𝑑)) because it includes the behavioral change and crowding effect of the infective individuals and prevents the unboundedness of the contact rate by choosing suitable parameters.

On the one hand, the newborns of the infectious may already be infected with the disease at birth such as hepatitis and phthisis, and so forth. This is called vertical transmission. On the other hand, some diseases may be spread from one individual to another via horizontal contacting transmission. Some epidemic models with vertical transmission were studied by many authors. However, only a few literatures [13] deal with the analysis of disease with pulse vaccination, vertical and horizontal transmissions.

Most of the research literature on these epidemic models are established by ODE, delayed ODE or impulsive ODE. However, impulsive equations with time delay are not many [14, 15]. In this paper, we establish a delayed SEIRS epidemic disease model with pulse vaccination and nonlinear incidence rate. We study their dynamic behaviors, establish sufficient condition for disease-eradication, as well as investigate the role of incubation in disease transmission. The main feature of this paper is to introduce time delay and pulse vaccination into epidemic model and obtain some important qualitative properties with valid pulse vaccination strategy.

The organization of this paper is as follows. In the next section, we introduce the delayed SEIRS model with pulse vaccination. To prove our main results, we also give several definitions, notations, and lemmas. In Section 3, we investigate the dynamic behavior of the model with nonlinear incidence and the sufficient condition is obtained for the global attractivity of infection-free periodic solution and the permanence of the model. In the final section, we try to interpret our mathematical results in terms of their ecological implication and also point out some future research directions.

2. Model Formulation and Preliminary

In the following model, we study a population that is partitioned into four classes, the susceptible, exposed, infectious, and recovered, with sizes denoted by S, E, I, and R, respectively, and we consider pulse vaccination strategy in the delayed SEIRS epidemic model with nonlinear incidence rate 𝛽(𝑆/(1+π‘Žπ‘†))𝐼, the following mathematical model is formulated: π‘†ξ…ž(𝑑)=π΄βˆ’π›½π‘†(𝑑)𝐼(𝑑)𝐸1+π‘Žπ‘†(𝑑)βˆ’πœ‡π‘†(𝑑)βˆ’(1βˆ’π‘)πœ‡πΌ(𝑑)+𝛼𝑅(𝑑),𝑑≠𝑛𝑇,ξ…ž(𝑑)=𝛽𝑆(𝑑)𝐼(𝑑)1+π‘Žπ‘†(𝑑)βˆ’π›½π‘’βˆ’πœ‡πœπ‘†(π‘‘βˆ’πœ)𝐼(π‘‘βˆ’πœ)𝐼1+π‘Žπ‘†(π‘‘βˆ’πœ)βˆ’πœ‡πΈ(𝑑)+(1βˆ’π‘)πœ‡πΌ(𝑑),𝑑≠𝑛𝑇,ξ…ž(𝑑)=π›½π‘’βˆ’πœ‡πœπ‘†(π‘‘βˆ’πœ)𝐼(π‘‘βˆ’πœ)𝑅1+π‘Žπ‘†(π‘‘βˆ’πœ)βˆ’(π‘Ÿ+𝑑+πœ‡)𝐼(𝑑),𝑑≠𝑛𝑇,ξ…ž(𝑑)=π‘ŸπΌ(𝑑)βˆ’πœ‡π‘…(𝑑)βˆ’π›Όπ‘…(𝑑),𝑑≠𝑛𝑇,𝑆(𝑑+)=(1βˆ’πœƒ)𝑆(𝑑),𝑑=𝑛𝑇,𝑛=1,2,…𝐸(𝑑+)=𝐸(𝑑),𝑑=𝑛𝑇,𝑛=1,2,…𝐼(𝑑+)=𝐼(𝑑),𝑑=𝑛𝑇,𝑛=1,2,…𝑅(𝑑+)=𝑅(𝑑)+πœƒπ‘†(𝑑),𝑑=𝑛𝑇,𝑛=1,2,….(2.1)

Here, all coefficients are positive constants, 𝐴 denotes the influx or recruitment of the susceptible and the exposed. The death rate for disease and physical disease rate are 𝑑 and πœ‡, respectively. π‘Ÿ is the recovery rate of infectious individual. πœƒ(0<πœƒ<1) is the proportion of those vaccinated successfully, which is called impulsive vaccination rate. 𝜏 is the latent period of the disease. Consider the death of exposed individuals during latent period of disease, that is, π›½π‘’βˆ’πœ‡πœ(𝑆(π‘‘βˆ’πœ)𝐼(π‘‘βˆ’πœ)/(1+π‘Žπ‘†(π‘‘βˆ’πœ))) term. The disease is propagated both vertically and horizontally, π‘πœ‡πΌ(0<𝑝<1) is the number of newborns of infectious who transfer to the susceptible class, and (1βˆ’π‘)πœ‡πΌ is the number of newborns of the infectious who are infected vertically.

The total population size 𝑁(𝑑)=𝑆(𝑑)+𝐸(𝑑)+𝐼(𝑑)+𝑅(𝑑) can be determined by the differential equationπ‘ξ…ž(𝑑)=π΄βˆ’πœ‡π‘(𝑑)βˆ’π‘‘πΌ(𝑑),(2.2)which is derived by adding all equations in system (2.1). So we have π΄βˆ’(πœ‡+𝑑)𝑁(𝑑)β‰€π‘ξ…ž(𝑑)β‰€π΄βˆ’πœ‡π‘(𝑑). It follows thatπ΄πœ‡+𝑑≀limπ‘‘β†’βˆžinf𝑁(𝑑)≀limπ‘‘β†’βˆžπ΄sup𝑁(𝑑)β‰€πœ‡.(2.3)

Before going to any detail, we simplify model (2.1) and mainly discuss the following model:π‘†ξ…ž(𝑑)=π΄βˆ’π›½π‘†(𝑑)𝐼(𝑑)𝐼1+π‘Žπ‘†(𝑑)βˆ’πœ‡π‘†(𝑑)βˆ’(1βˆ’π‘)πœ‡πΌ(𝑑)+𝛼𝑅(𝑑),𝑑≠𝑛𝑇,ξ…ž(𝑑)=π›½π‘’βˆ’πœ‡πœπ‘†(π‘‘βˆ’πœ)𝐼(π‘‘βˆ’πœ)𝑅1+π‘Žπ‘†(π‘‘βˆ’πœ)βˆ’(π‘Ÿ+𝑑+πœ‡)𝐼(𝑑),𝑑≠𝑛𝑇,ξ…žπ‘(𝑑)=π‘ŸπΌ(𝑑)βˆ’πœ‡π‘…(𝑑)βˆ’π›Όπ‘…(𝑑),𝑑≠𝑛𝑇,ξ…ž(𝑑)=π΄βˆ’πœ‡π‘(𝑑)βˆ’π‘‘πΌ(𝑑),𝑑≠𝑛𝑇,𝑆(𝑑+)=(1βˆ’πœƒ)𝑆(𝑑),𝑑=𝑛𝑇,𝑛=1,2,…𝐼(𝑑+)=𝐼(𝑑),𝑑=𝑛𝑇,𝑛=1,2,…𝑅(𝑑+)=𝑅(𝑑)+πœƒπ‘†(𝑑),𝑑=𝑛𝑇,𝑛=1,2,…𝑁(𝑑+)=𝑁(𝑑),𝑑=𝑛𝑇,𝑛=1,2,….(2.4)The initial condition of (2.4) is given asπœ™(πœ‰)=(πœ™1(πœ‰),πœ™2(πœ‰),πœ™3(πœ‰),πœ™4(πœ‰))∈𝐢+,πœ™π‘–(0)>0,𝑖=1,2,3,4,(2.5)where 𝐢+=𝐢([βˆ’πœ,0],𝑅4+). From biological considerations, we discuss system (2.4) in the closed setΩ=(𝑆,𝐼,𝑅,𝑁)βˆˆπ‘…4+𝐴∣0≀𝑆+𝐼+π‘…β‰€πœ‡π΄,π‘β‰€πœ‡ξ‚‡,(2.6)where 𝑅4+ denotes the nonnegative cone of 𝑅4 including its lower dimensional faces. It is easy to show that Ξ© is positively invariant with respect to (2.4).

Before starting our main results, we give the following lemmas. Lemma 2.1 (See [16]). Consider the following delay differential equation: π‘₯ξ…ž(𝑑)=π‘Žπ‘₯(π‘‘βˆ’πœ)βˆ’π‘π‘₯(𝑑),(2.7)where π‘Ž,𝑏,𝜏>0 and π‘₯(𝑑)>0 for π‘‘βˆˆ[βˆ’πœ,0]. The following hold:
(i)if π‘Ž<𝑏, then limπ‘‘β†’βˆžπ‘₯(𝑑)=0,(ii)if π‘Ž>𝑏, then limπ‘‘β†’βˆžπ‘₯(𝑑)=+∞.
Lemma 2.2. Consider the following impulsive differential equations: π‘’ξ…ž(𝑑)=π‘Žβˆ’π‘π‘’(𝑑),𝑑≠𝑛𝑇,𝑒(𝑑+)=(1βˆ’πœƒ)𝑒(𝑑),𝑑=𝑛𝑇,π‘›βˆˆπ‘,(2.8)where π‘Ž>0,𝑏>0,0<πœƒ<1. Then there exists a unique positive periodic solution of (2.8): ξ‚π‘’π‘’π‘Ž(𝑑)=𝑏+ξ‚€π‘’βˆ—βˆ’π‘Žπ‘ξ‚π‘’βˆ’π‘(π‘‘βˆ’π‘˜π‘‡),π‘˜π‘‡<𝑑<(π‘˜+1)𝑇,(2.9)which is globally asymptotically stable, where π‘’βˆ—=π‘Ž(1βˆ’πœƒ)(1βˆ’π‘’βˆ’π‘π‘‡)/𝑏(1βˆ’(1βˆ’πœƒ)π‘’βˆ’π‘π‘‡).

3. Global Attractivity of Infection-Free Periodic Solution

In this section, we study the existence of the infection-free periodic solution of system (2.4), in which infectious individuals are entirely absent from the population permanently, that is, 𝐼(𝑑)=0 for all 𝑑β‰₯0. Under this condition, system (2.4) becomes the following impulsive system without delay: π‘†ξ…žπ‘…(𝑑)=π΄βˆ’πœ‡π‘†(𝑑)+𝛼𝑅(𝑑),𝑑≠𝑛𝑇,ξ…žπ‘(𝑑)=πœ‡π‘…(𝑑)βˆ’π›Όπ‘…(𝑑),𝑑≠𝑛𝑇,ξ…ž(𝑑)=π΄βˆ’πœ‡π‘(𝑑),𝑑≠𝑛𝑇,𝑆(𝑑+)=(1βˆ’πœƒ)𝑆(𝑑),𝑑=𝑛𝑇,𝑛=1,2,…𝑅(𝑑+)=𝑅(𝑑)+πœƒπ‘†(𝑑),𝑑=𝑛𝑇,𝑛=1,2,…𝑁(𝑑+)=𝑁(𝑑),𝑑=𝑛𝑇,𝑛=1,2,….(3.1) From the third and sixth equations of system (3.1), we have limπ‘‘β†’βˆžπ‘(𝑑)=𝐴/πœ‡. Further, if 𝐼(𝑑)=0, it follows that limπ‘‘β†’βˆžπΈ(𝑑)=0 from the second and sixth equations of system (2.1). In the following, we show that the susceptible population 𝑆 and recovered population 𝑅 oscillate with period 𝑇, in synchronization with the periodic impulsive vaccination. Consider the following limit system of system (3.1): 𝐴𝑅(𝑑)=πœ‡π‘†βˆ’π‘†(𝑑),ξ…žξ‚€π΄(𝑑)=(𝛼+πœ‡)πœ‡ξ‚βˆ’π‘†(𝑑),𝑑≠𝑛𝑇,𝑆(𝑑+)=(1βˆ’πœƒ)𝑆(𝑑),𝑑=𝑛𝑇,π‘›βˆˆπ‘.(3.2)By Lemma 2.2, we know that the periodic solution of system (3.2), 𝑆𝑒𝐴(𝑑)=πœ‡+ξ‚€π‘†βˆ—βˆ’π΄πœ‡ξ‚π‘’βˆ’(𝛼+πœ‡)(π‘‘βˆ’π‘›π‘‡),𝑛𝑇<𝑑≀(𝑛+1)𝑇,(3.3)is globally asymptotically stable, where π‘†βˆ—=𝐴(1βˆ’πœƒ)(1βˆ’π‘’βˆ’(𝛼+πœ‡)𝑇)/πœ‡(1βˆ’(1βˆ’πœƒ)π‘’βˆ’(𝛼+πœ‡)𝑇).

Denote 𝑅1=π›½π‘’βˆ’πœ‡πœπ›Ώ/(1+π‘Žπ›Ώ)(π‘Ÿ+𝑑+πœ‡), where 𝛿=𝐴(1βˆ’π‘’βˆ’(𝛼+πœ‡)𝑇)/πœ‡(1βˆ’(1βˆ’πœƒ)π‘’βˆ’(𝛼+πœ‡)𝑇).

Theorem 3.1. If 𝑅1<1, then the infection-free periodic solution (𝑆𝑒𝑆(𝑑),0,𝐴/πœ‡βˆ’π‘’(𝑑),𝐴/πœ‡) of system (2.4) is globally attractive.Proof. Since 𝑅1<1, we can choose πœ€>0 small enough such thatπ›½π‘’βˆ’πœ‡πœ(𝛿+πœ€)1+π‘Ž(𝛿+πœ€)<π‘Ÿ+𝑑+πœ‡.(3.4)From the first equation of system (2.4), it follows that π‘†ξ…ž(𝑑)≀(𝛼+πœ‡)((𝐴/πœ‡)βˆ’π‘†(𝑑)). Thus consider the following comparison impulsive differential system:π‘§ξ…žξ‚€π΄(𝑑)=(𝛼+πœ‡)πœ‡ξ‚βˆ’π‘§(𝑑),𝑑≠𝑛𝑇,𝑧(𝑑+)=(1βˆ’πœƒ)𝑧(𝑑),𝑑=𝑛𝑇,π‘›βˆˆπ‘.(3.5)By (3.2), we know that the periodic solution of system (3.5),𝑧𝑒𝑆(𝑑)=𝑒𝐴(𝑑)=πœ‡+ξ‚€π‘†βˆ—βˆ’π΄πœ‡ξ‚π‘’βˆ’(𝛼+πœ‡)(π‘‘βˆ’π‘›π‘‡),𝑛𝑇<𝑑≀(𝑛+1)𝑇,(3.6)is globally asymptotically stable, where π‘†βˆ—=𝐴(1βˆ’πœƒ)(1βˆ’π‘’βˆ’(𝛼+πœ‡)𝑇)/πœ‡(1βˆ’(1βˆ’πœƒ)π‘’βˆ’(𝛼+πœ‡)𝑇). Let (𝑆(𝑑),𝐼(𝑑),𝑅(𝑑),𝑁(𝑑)) be the solution of system (2.4) with initial condition (2.5) and 𝑆(0+)=𝑆0>0,𝑧(𝑑) be the solution of system (3.5) with initial value 𝑧(0+)=𝑆0. By the comparison theorem for impulsive differential equations [17], there exists an integer 𝑛1>0 such that𝑆(𝑑)<𝑧(𝑑)<𝑧𝑒(𝑑)+πœ€,𝑛𝑇<𝑑≀(𝑛+1)𝑇,𝑛>𝑛1,(3.7)that is,𝑆(𝑑)<𝑧𝑒𝐴(𝑑)+πœ€β‰€1βˆ’π‘’βˆ’(𝛼+πœ‡)π‘‡ξ‚πœ‡ξ‚€1βˆ’(1βˆ’πœƒ)π‘’βˆ’(𝛼+πœ‡)𝑇+πœ€β‰πœ‚.(3.8)Further, from the second equation of system (2.4), we have that, for all 𝑑>𝑛𝑇+𝜏,𝑛>𝑛1,πΌξ…ž(𝑑)β‰€π›½πœ‚π‘’βˆ’πœ‡πœ1+π‘Žπœ‚πΌ(π‘‘βˆ’πœ)βˆ’(π‘Ÿ+𝑑+πœ‡)𝐼(𝑑).(3.9)Consider the following comparison equation:π‘¦ξ…ž(𝑑)=π›½πœ‚π‘’βˆ’πœ‡πœ1+π‘Žπœ‚π‘¦(π‘‘βˆ’πœ)βˆ’(π‘Ÿ+𝑑+πœ‡)𝑦(𝑑).(3.10)From (3.4), we have thatπ›½πœ‚π‘’βˆ’πœ‡πœ1+π‘Žπœ‚<(π‘Ÿ+𝑑+πœ‡).(3.11)According to Lemma 2.1, we obtain that limπ‘‘β†’βˆžπ‘¦(𝑑)=0.
Set (𝑆(𝑑),𝐼(𝑑),𝑅(𝑑),𝑁(𝑑)) be the solution of system (2.4) with initial condition (2.5) and 𝐼(πœ‰)=πœ™(πœ‰)>0(πœ‰βˆˆ[βˆ’πœ,0]),𝑦(𝑑) be the solution of (3.10) with initial condition 𝑦(πœ‰)=πœ™(πœ‰)>0(πœ‰βˆˆ[βˆ’πœ,0]). By the comparison theorem in differential equation and the positivity of solution (with 𝐼(𝑑)β‰₯0), we have thatlimπ‘‘β†’βˆžπΌ(𝑑)=0.(3.12)Therefore, for any πœ€1>0 (sufficiently small), there exists an 𝑛2(𝑛2𝑇>𝑛1𝑇+𝜏) such that 0<𝐼(𝑑)<πœ€1 for all 𝑑>𝑛2𝑇. By the fourth equation of system (2.4), we haveπ‘ξ…ž(𝑑)>π΄βˆ’πœ‡π‘(𝑑)βˆ’π‘‘πœ€1for𝑑>𝑛2𝑇.(3.13)Consider the following comparison equation: π‘§ξ…ž1(𝑑)=(π΄βˆ’π‘‘πœ€1)βˆ’πœ‡π‘§1(𝑑).
It is clear that limπ‘‘β†’βˆžπ‘§1(𝑑)=(π΄βˆ’π‘‘πœ€1)/πœ‡; by the comparison theorem, we have that there exists an integer 𝑛3>𝑛2 such that for all 𝑑>𝑛3𝑇,𝑁(𝑑)β‰₯(π΄βˆ’π‘‘πœ€1)/πœ‡βˆ’πœ€1. Since πœ€1 is arbitrarily small, we havelimπ‘‘β†’βˆžπ΄π‘(𝑑)=πœ‡.(3.14)It follows from (3.12) and (3.14) that, there exists 𝑛4>𝑛3 such that𝐼(𝑑)<πœ€1𝐴,𝑁(𝑑)>πœ‡βˆ’πœ€1for𝑑>𝑛4𝑇.(3.15)From the second equation of system (2.1), we have πΈξ…žξ‚€(𝑑)β‰€π΄π›½πœ€1πœ‡+π‘Žπ΄+(1βˆ’π‘)πœ‡πœ€1ξ‚βˆ’πœ‡πΈ(𝑑)for𝑑>𝑛4𝑇.(3.16) It is easy to obtain that there exists an 𝑛5>𝑛4 such that 𝐸(𝑑)<𝛿1+πœ€1for𝑑>𝑛5𝑇,(3.17)where 𝛿1=(π΄π›½πœ€1+(πœ‡+π‘Žπ΄)(1βˆ’π‘)πœ‡πœ€1)/πœ‡(πœ‡+π΄π‘Ž). So from the first equation of system (2.4), we have π‘†ξ…žξ‚€(𝑑)β‰₯𝐴+π›Όπ΄πœ‡βˆ’(1βˆ’π‘)πœ‡πœ€1βˆ’π›Όπ›Ώ1βˆ’3π›Όπœ€1ξ‚βˆ’ξ‚€π›½πœ€1+πœ‡+𝛼𝑆(𝑑).(3.18)Consider the following comparison impulsive differential equations for 𝑑>𝑛5𝑇 and 𝑛>𝑛5: π‘’ξ…žξ‚€(𝑑)=𝐴+π›Όπ΄πœ‡βˆ’(1βˆ’π‘)πœ‡πœ€1βˆ’π›Όπ›Ώ1βˆ’3π›Όπœ€1ξ‚βˆ’ξ‚€π›½πœ€1+πœ‡+𝛼𝑒(𝑑),𝑑≠𝑛𝑇,𝑒(𝑑+)=(1βˆ’πœƒ)𝑒(𝑑),𝑑=𝑛𝑇,π‘›βˆˆπ‘.(3.19)By Lemma 2.2, we know that the periodic solution of system (3.19) is𝑒𝑒(𝑑)=Θ+(π‘’βˆ—βˆ’Ξ˜)π‘’βˆ’(𝛼+πœ‡+π›½πœ€1)(π‘‘βˆ’π‘›π‘‡),𝑛𝑇<𝑑≀(𝑛+1)𝑇,(3.20)which is globally asymptotically stable, where Θ=𝐴+𝐴𝛼/πœ‡βˆ’π›Όπ›Ώ1βˆ’3π›Όπœ€1βˆ’(1βˆ’π‘)πœ‡πœ€1𝛼+πœ‡+π›½πœ€1,π‘’βˆ—ξ‚€=Θ(1βˆ’πœƒ)1βˆ’π‘’βˆ’(𝛼+πœ‡+π›½πœ€1)𝑇1βˆ’(1βˆ’πœƒ)π‘’βˆ’(𝛼+πœ‡+π›½πœ€1)𝑇.(3.21)By using the comparison theorem of impulsive differential equation [17], there exists an 𝑛6>𝑛5 such that𝑆(𝑑)>𝑒𝑒(𝑑)βˆ’πœ€1,𝑛𝑇<𝑑≀(𝑛+1)𝑇,𝑛>𝑛6.(3.22)Let πœ€1β†’0, then it follows from (3.8) and (3.22) that 𝑆𝑒𝐴(𝑑)=πœ‡ξ‚€1βˆ’πœƒπ‘’βˆ’(𝛼+πœ‡)(π‘‘βˆ’π‘›π‘‡)1βˆ’(1βˆ’πœƒ)π‘’βˆ’(𝛼+πœ‡)𝑇,𝑛𝑇<𝑑≀(𝑛+1)𝑇,(3.23)is globally attractive, that is,limπ‘‘β†’βˆžξ‚‹π‘†π‘†(𝑑)=𝑒(𝑑).(3.24)By the positivity of 𝐸(𝑑) and sufficiently small πœ€1, it follows from (3.17) that limπ‘‘β†’βˆžπΈ(𝑑)=0.(3.25) From the restriction 𝑁(𝑑)=𝑆(𝑑)+𝐸(𝑑)+𝐼(𝑑)+𝑅(𝑑), we have limπ‘‘β†’βˆžξ‚‹π‘†π‘…(𝑑)=𝐴/πœ‡βˆ’π‘’(𝑑). Therefore, the infection-free periodic solution (𝑆𝑒𝑆(𝑑),0,𝐴/πœ‡βˆ’π‘’(𝑑),𝐴/πœ‡) is globally attractive. This completes the proof.
Corollary 3.2. In system (2.4), the following states are true.
(i)If π΄π›½π‘’βˆ’πœ‡πœ<(π‘Ÿ+𝑑+πœ‡)(πœ‡+π΄π‘Ž),then infection-free periodic solution (𝑆𝑒𝑆(𝑑),0,𝐴/πœ‡βˆ’π‘’(𝑑),𝐴/πœ‡) is globally attractive.(ii)If π΄π›½π‘’βˆ’πœ‡πœ>(π‘Ÿ+𝑑+πœ‡)(πœ‡+π΄π‘Ž) and 𝑇<π‘‡βˆ—, then infection-free periodic solution (𝑆𝑒𝑆(𝑑),0,𝐴/πœ‡βˆ’π‘’(𝑑),𝐴/πœ‡) is globally attractive, where π‘‡βˆ—=1/(𝛼+πœ‡)ln(1+(πœƒ(π‘Ÿ+𝑑+πœ‡)πœ‡)/(π΄π›½π‘’βˆ’πœ‡πœβˆ’π‘Žπ΄(π‘Ÿ+𝑑+πœ‡)βˆ’(π‘Ÿ+𝑑+πœ‡)πœ‡).(iii)If πœƒ>πœƒβˆ—, then infection-free periodic solution (𝑆𝑒𝑆(𝑑),0,𝐴/πœ‡βˆ’π‘’(𝑑),𝐴/πœ‡) is globally attractive, where πœƒβˆ—=(π‘Ÿ+π‘‘πœ‡)π‘’βˆ’(𝛼+πœ‡)π‘‡βˆ’(π‘Ÿ+𝑑+πœ‡)πœ‡+(π΄π›½π‘’βˆ’πœ‡πœβˆ’π‘Ž(π‘Ÿ+𝑑+πœ‡)𝐴)(1βˆ’π‘’βˆ’(𝛼+πœ‡)𝑇)/πœ‡(π‘Ÿ+𝑑+πœ‡)π‘’βˆ’(𝛼+πœ‡)𝑇.

Theorem 3.1 determines the global attractivity of system (2.4) in Ξ© for the case 𝑅1<1. From Corollary 3.2, we can see that a short pulse periodic (with 𝑇) or a large pulse vaccination rate (with πœƒ) is the sufficient condition for the global attractivity of infection-free periodic solution (𝑆𝑒𝑆(𝑑),0,𝐴/πœ‡βˆ’π‘’(𝑑),𝐴/πœ‡).

4. Permanence

In this section, it is noted that the disease is endemic if the infectious population persists above a certain threshold for sufficiently large time. The endemicity of the disease can be well captured and studied through the notion of uniform persistence and permanence.Definition 4.1. System (2.4) is said to be uniformly persistent if there exists an π‘š>0 (independent of the initial data) such that every solution (𝑆(𝑑),𝐼(𝑑),𝑅(𝑑),𝑁(𝑑)) with initial conditions (2.5) of system (2.4) satisfieslimπ‘‘β†’βˆžinf𝑆(𝑑)β‰₯π‘š,limπ‘‘β†’βˆžinf𝐼(𝑑)β‰₯π‘š,limπ‘‘β†’βˆžinf𝑅(𝑑)β‰₯π‘š,limπ‘‘β†’βˆžinf𝑁(𝑑)β‰₯π‘š.(4.1)Definition 4.2. System (2.4) is said to be permanent if there exists a compact region Ξ©0∈intΞ© such that every solution of system (2.4) with initial data (2.5) will eventually enter and remain in region Ξ©0.

Denote𝑅2=ξ‚€π›½π‘’βˆ’πœ‡πœξ‚ξ‚€/(π‘Ÿ+𝑑+πœ‡)βˆ’π‘Žπ΄(1βˆ’πœƒ)1βˆ’π‘’βˆ’πœ‡π‘‡ξ‚πœ‡ξ‚€1βˆ’(1βˆ’πœƒ)π‘’βˆ’πœ‡π‘‡ξ‚,πΌβˆ—=ξ‚€π‘…π΄πœ‡2ξ‚βˆ’1𝐴𝛽+(1βˆ’π‘)πœ‡2𝑅2.(4.2)

Theorem 4.3. If 𝑅2>1, then there exists a positive constant π‘š such that each positive solution (𝑆(𝑑),𝐼(𝑑),𝑅(𝑑),𝑁(𝑑)) of system (2.4) satisfies 𝐼(𝑑)β‰₯π‘š for 𝑑 large enough.Proof. Note that the second equation of system (2.4) can be rewritten as follows:πΌξ…žξ‚€(𝑑)=𝐼(𝑑)π›½π‘’βˆ’πœ‡πœπ‘†(𝑑)1+π‘Žπ‘†(𝑑)βˆ’(π‘Ÿ+𝑑+πœ‡)βˆ’π›½π‘’βˆ’πœ‡πœπ‘‘ξ€œπ‘‘π‘‘π‘‘π‘‘βˆ’πœπ‘†(𝑒)𝐼(𝑒)1+π‘Žπ‘†(𝑒)𝑑𝑒.(4.3)Define𝑉(𝑑)=𝐼(𝑑)+π›½π‘’βˆ’πœ‡πœξ€œπ‘‘π‘‘βˆ’πœπ‘†(𝑒)1+π‘Žπ‘†(𝑒)𝐼(𝑒)𝑑𝑒.(4.4)According to (4.3), we calculate the derivative of 𝑉 along the solution of (2.4):π‘‰ξ…žξ‚€(𝑑)=𝐼(𝑑)π›½π‘’βˆ’πœ‡πœπ‘†(𝑑)1+π‘Žπ‘†(𝑑)βˆ’(π‘Ÿ+𝑑+πœ‡)=(π‘Ÿ+𝑑+πœ‡)𝐼(𝑑)π›½π‘’βˆ’πœ‡πœπ‘†(𝑑).(π‘Ÿ+𝑑+πœ‡)(1+π‘Žπ‘†(𝑑))βˆ’1(4.5)Since 𝑅2>1, then πΌβˆ—>0 and there exists sufficiently small πœ€>0 such thatπ›½π‘’βˆ’πœ‡πœπœŽ(π‘Ÿ+𝑑+πœ‡)(1+π‘ŽπœŽ)>1,(4.6)whereξ‚€πœŽ=π΄βˆ’(1βˆ’π‘)πœ‡πΌβˆ—ξ‚ξ‚€(1βˆ’πœƒ)1βˆ’π‘’βˆ’(π›½πΌβˆ—+πœ‡)𝑇(π›½πΌβˆ—ξ‚€+πœ‡)1βˆ’(1βˆ’πœƒ)π‘’βˆ’(π›½πΌβˆ—+πœ‡)π‘‡ξ‚βˆ’πœ€>0.(4.7)We claim that for any 𝑑0>0, it is impossible that 𝐼(𝑑)<πΌβˆ— for all 𝑑β‰₯𝑑0. Otherwise, there is a 𝑑0>0 such that 𝐼(𝑑)<πΌβˆ— for all 𝑑β‰₯𝑑0. It follows from the first equation of (2.4) that we haveπ‘†ξ…žξ‚€(𝑑)>π΄βˆ’(1βˆ’π‘)πœ‡πΌβˆ—ξ‚βˆ’(π›½πΌβˆ—+πœ‡)𝑆(𝑑).(4.8)Consider the following comparison impulsive system for 𝑑β‰₯𝑑0:π‘£ξ…žξ‚€(𝑑)=π΄βˆ’(1βˆ’π‘)πœ‡πΌβˆ—ξ‚βˆ’(π›½πΌβˆ—+πœ‡)𝑣(𝑑),𝑑≠𝑛𝑇,𝑣(𝑑+)=(1βˆ’πœƒ)𝑣(𝑑),𝑑=𝑛𝑇,π‘›βˆˆπ‘.(4.9)According to Lemma 2.2, we obtain that𝑣𝑒(𝑑)=π΄βˆ’(1βˆ’π‘)πœ‡πΌβˆ—π›½πΌβˆ—+𝑣+πœ‡βˆ—βˆ’π΄βˆ’(1βˆ’π‘)πœ‡πΌβˆ—π›½πΌβˆ—ξ‚π‘’+πœ‡βˆ’(π›½πΌβˆ—+πœ‡)(π‘‘βˆ’π‘›π‘‡),𝑛𝑇<𝑑≀(𝑛+1)𝑇,(4.10)is the unique globally asymptotically stable positive periodic solution, where π‘£βˆ—=
By the comparison theorem for impulsive differential equation [17], we know that there exists (π΄βˆ’(1βˆ’π‘)πœ‡πΌβˆ—) such that the following inequality holds for (1βˆ’πœƒ):(1βˆ’π‘’βˆ’(π›½πΌβˆ—+πœ‡)𝑇)Thus/(π›½πΌβˆ—+πœ‡)(1βˆ’(1βˆ’πœƒ)π‘’βˆ’(π›½πΌβˆ—+πœ‡)𝑇).From (4.6), we have 𝑑1>𝑑0+𝜏 By (4.5) and (4.12), we have𝑑>𝑑1Let𝑣𝑆(𝑑)>𝑒(𝑑)βˆ’πœ€.(4.11)We will show that 𝑆(𝑑)>π‘£βˆ—βˆ’πœ€β‰πœŽ>0for𝑑β‰₯𝑑1.(4.12) for all π›½π‘’βˆ’πœ‡πœπœŽ/(π‘Ÿ+𝑑+πœ‡)(1+π‘ŽπœŽ)>1.. Otherwise, there is a π‘‰ξ…žξ‚€(𝑑)>(π‘Ÿ+𝑑+πœ‡)𝐼(𝑑)π›½π‘’βˆ’πœ‡πœπœŽξ‚(π‘Ÿ+𝑑+πœ‡)(1+π‘ŽπœŽ)βˆ’1for𝑑β‰₯𝑑1.(4.13) such that 𝐼𝑙=minπ‘‘βˆˆ[𝑑1,𝑑1+𝜏]𝐼(𝑑).(4.14) for 𝐼(𝑑)β‰₯𝐼𝑙 and 𝑑β‰₯𝑑1. However, the second equation of systems (2.4) and (4.12) imply that𝑇0>0This is a contradiction, thus, 𝐼(𝑑)β‰₯𝐼𝑙 for all π‘‘βˆˆ[𝑑1,𝑑1+𝜏+𝑇0],𝐼(𝑑1+𝜏+𝑇0)=𝐼𝑙,. As a consequence, (4.13) leads toπΌξ…ž(𝑑1+𝜏+𝑇0)≀0which implies that πΌξ…žξ‚€π‘‘1+𝜏+𝑇0β‰₯(π‘Ÿ+𝑑+πœ‡)πΌπ‘™ξ‚€π›½π‘’βˆ’πœ‡πœπœŽξ‚(π‘Ÿ+𝑑+πœ‡)(1+π‘ŽπœŽ)βˆ’1>0.(4.15) as 𝐼(𝑑)β‰₯𝐼𝑙 This contradicts with 𝑑β‰₯𝑑1 Hence, for any π‘‰ξ…ž(𝑑)>(π‘Ÿ+𝑑+πœ‡)πΌπ‘™ξ‚€π›½π‘’βˆ’πœ‡πœπœŽξ‚(π‘Ÿ+𝑑+πœ‡)(1+π‘ŽπœŽ)βˆ’1>0for𝑑β‰₯𝑑1,(4.16) the inequality 𝑉(𝑑)β†’βˆž cannot hold for all π‘‘β†’βˆž. Next, we are left to consider two cases:
(1)𝑉(𝑑)≀(𝐴/πœ‡)(1+π΄πœπ›½π‘’βˆ’πœ‡πœ/πœ‡). for 𝑑0>0, large enough;(2)𝐼(𝑑)<πΌβˆ— oscillates about 𝑑β‰₯𝑑0. for 𝐼(𝑑)β‰₯πΌβˆ— large enough.It is clear that if 𝑑 for 𝐼(𝑑) large enough, then our aim is obtained. So we only need consider the case πΌβˆ—
Let𝑑In the following, we will show that 𝐼(𝑑)β‰₯πΌβˆ— for 𝑑 large enough, let (2). and ξ‚†πΌπ‘š=minβˆ—2,πΌβˆ—π‘’βˆ’(π‘Ÿ+𝑑+πœ‡)πœξ‚‡.(4.17) satisfy 𝐼(𝑑)β‰₯π‘š and 𝑑 for π‘‘βˆ—>0 where πœ„>0 is sufficiently large such that 𝐼(π‘‘βˆ—)=𝐼(πœ„+π‘‘βˆ—)=πΌβˆ—, for 𝐼(𝑑)<πΌβˆ— we can conclude that π‘‘βˆ—<𝑑<π‘‘βˆ—+πœ„, is uniformly continuous since the positive solution of (2.4) is ultimately bounded and π‘‘βˆ— is not affected by impulsive effects. Hence there exists a constant 𝑆(𝑑)>𝜎 and π‘‘βˆ—<𝑑<π‘‘βˆ—+πœ„, is independent of the choice if 𝐼(𝑑) such that 𝐼(𝑑) for 𝑇1(0<𝑇1<𝜏, If 𝑇1our aim is obtained. If π‘‘βˆ—), since 𝐼(𝑑)>πΌβˆ—/2, and π‘‘βˆ—β‰€π‘‘β‰€π‘‘βˆ—+𝑇1., it is obvious that πœ„β‰€π‘‡1, for 𝑇1<πœ„β‰€πœ. If πΌξ…ž(𝑑)>βˆ’(π‘Ÿ+𝑑+πœ‡)𝐼(𝑑) by the second equation of (2.4), we obtain 𝐼(π‘‘βˆ—)=πΌβˆ— for 𝐼(𝑑)β‰₯πΌβˆ—π‘’βˆ’(π‘Ÿ+𝑑+πœ‡)𝜏 The same arguments can be continued, we can obtain π‘‘βˆ—<𝑑<π‘‘βˆ—+πœ„ for πœ„>𝜏;. Since the interval 𝐼(𝑑)β‰₯πΌβˆ—π‘’βˆ’(π‘Ÿ+𝑑+πœ‡)𝜏 is arbitrarily chosen, we can conclude that π‘‘βˆ—<𝑑<π‘‘βˆ—+𝜏. for 𝐼(𝑑)β‰₯πΌβˆ—π‘’βˆ’(π‘Ÿ+𝑑+πœ‡)𝜏 large enough. Based on the above discussions, the choice of π‘‘βˆ—+𝜏<𝑑<π‘‘βˆ—+πœ„ is independent of the positive solution of (2.4), and we have proved that any positive solution of (2.4) satisfies [π‘‘βˆ—,π‘‘βˆ—+πœ„] for all sufficiently large 𝐼(𝑑)β‰₯π‘š. This completes the proof.
Theorem 4.4. If 𝑑 then the system (2.4) is permanent.Proof. Suppose that π‘š be any solution of (2.4). From the first equation of (2.4), we have𝐼(𝑑)β‰₯π‘šSimilarly, we have𝑑where𝑅2>1,By Theorem 4.3, the third equation of (2.4) becomes(𝑆(𝑑),𝐼(𝑑),𝑅(𝑑),𝑁(𝑑))It is easy to obtain thatπ‘†ξ…žξ‚€(𝑑)β‰₯π‘π΄βˆ’π›½π΄πœ‡ξ‚+πœ‡π‘†(𝑑).(4.18)
Setlimπ‘‘β†’βˆžπ‘†(𝑑)β‰₯π‘ž,(4.19)By Theorem 3.1 and above discussions, we know that the set π‘ž=π‘π΄πœ‡π›½π΄+πœ‡2ξ‚€(1βˆ’πœƒ)1βˆ’π‘’βˆ’(𝛽(𝐴/πœ‡)+πœ‡)𝑇1βˆ’(1βˆ’πœƒ)π‘’βˆ’(𝛽(𝐴/πœ‡)+πœ‡)π‘‡βˆ’πœ€.(4.20) is a global attractor in π‘…ξ…ž(𝑑)β‰₯π‘Ÿπ‘šβˆ’(πœ‡+𝛼)𝑅(𝑑).(4.21) and, of course, every solution of system (2.4) with initial condition (2.5) will eventually enter and remain in region 𝑅(𝑑)β‰₯π‘Ÿπ‘šπœ‡+π›Όβˆ’πœ€β‰πœ”.(4.22). Hence system (2.4) is permanent. This completes the proof.
Denote Ξ©0=𝐴(𝑆,𝐼,𝑅,𝑁)βˆ£π‘žβ‰€π‘†,π‘šβ‰€πΌ,πœ”β‰€π‘…,𝑆+𝐼+π‘…β‰€πœ‡,π΄π΄πœ‡+π‘‘βˆ’πœ€β‰€π‘β‰€πœ‡ξ‚‡.(4.23)Corollary 4.5. The following results are true.
(1)If Ξ©0 then system (2.4) is permanent.(2)If Ξ© then system (2.4) is permanent.

5. Discussion

In this paper, we introduce the delayed SEIRS epidemic model with pulse vaccination and nonlinear incidence rate of the form Ξ©0 As a result, it is observed that nonlinear incidence, the latent period of disease, pulse vaccination rate, and pulse vaccination period bring effects on the dynamics of our model. Theorems 3.1 and 4.4 show that π‘‡βˆ—1=βˆ’πœ‡1lnξ‚€πœƒξ‚€1βˆ’πœƒ1βˆ’π›½π‘’βˆ’πœ‡πœ/ξ‚€ξ‚ξ‚π΄π‘Ÿ+𝑑+πœ‡βˆ’π‘Žξ‚€π›½π‘’βˆ’πœ‡πœ/,πœƒπ‘Ÿ+𝑑+πœ‡βˆ’π‘Žπ΄βˆ’πœ‡βˆ—=1βˆ’πœ‡π‘’πœ‡π‘‡π΄ξ‚€π›½π‘’βˆ’πœ‡πœ/ξ‚€ξ‚π‘’π‘Ÿ+𝑑+πœ‡βˆ’π‘Žξ‚ξ‚€πœ‡π‘‡ξ‚.βˆ’1+πœ‡(4.24) or 𝑇>π‘‡βˆ—, implies that the disease will be eradicated, whereas πœƒ<πœƒβˆ—, or 𝛽(𝑆(𝑑)𝐼(𝑑)/(1+π‘Žπ‘†(𝑑))). implies that the disease will be epidemic. Our results indicate that a short pulse time or a large pulse vaccinate rate will lead to eradication of the disease. In this paper, we only discuss 𝑅1<1,πœƒ>πœƒβˆ—, and 𝑇<π‘‡βˆ— but for closed interval 𝑅2>1,πœƒ<πœƒβˆ—, the dynamical behaviors of system (2.4) have not been studied, that is, the threshold parameter for the reproducing number between the eradication and the permanence of the disease has not been studied, which will be left in the future research.

Acknowledgment

This work was supported by National Natural Science Foundation of China (10771179).

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