Early Complication in Sickle Cell Anemia Children due to A(TA)_nTAA Polymorphism at the Promoter of UGT1A1 Gene

Table 2

Distribution of A(TA)_nTAA genotypes and allele frequency according to the presence or absence of cholelithiasis in the sample of patients.

	Children without cholelithiasis; 𝑁=50	Children with cholelithiasis; 𝑁=52	Control group; 𝑁=76	𝑃1	𝑃2
Genotypes
(TA)6/(TA)6	30	10	30	1*	1*
(TA)6/(TA)5	1	1	0	0.46	1
(TA)6/(TA)7	16	15	31	0.07	0.145
(TA)7/(TA)7	1	20	11	8.1×10^−8	9.5×10^−3
(TA)5/(TA)7	1	1	1	0.46	1
(TA)7/(TA)8	1	5	2	0.01	1
(TA)8/(TA)8	0	0	1	1	1
Allele frequency
(TA)6	0.77	0.346	0.598	1*	1*
(TA)5	0.02	0.019	0.0065	0.59	0.433
(TA)7	0.20	0.586	0.368	5.8×10^−9	0.310
(TA)8	0.01	0.048	0.025	0.01	0.664

1*: reference group.
𝑃: index of significance with Yates’s correction, each 𝑃<0.05 is considered as significant.
Control group: patients with normal hemoglobin status and presented cholelithiasis.
𝑃1: comparison between SCA patients according to the presence or the absence of cholelithiasis, 𝑃2: comparison between SCA patients without cholelithiasis and the control group.