Early Complication in Sickle Cell Anemia Children due to A(TA)_nTAA Polymorphism at the Promoter of UGT1A1 Gene

Table 3

(a) Repartition of different genotypes depending on two intervals representing bilirubin level in SCA children. (b) Repartition of different genotypes depending two intervals representing bilirubin level in the control group.

(a)

A(TA)nTAA genotypes	𝐴	𝐵	𝑃
(TA)6/(TA)5	2	0	—
(TA)5/(TA)7	2	0	—
(TA)6/(TA)6	40	0	1*
(TA)6/(TA)7	18	15	7.1×10^−7
(TA)7/(TA)7	0	20	2.4×10^−16
(TA)7/(TA)8	0	5	8.2×10^−7
Total	62	40

(b)

A(TA)nTAA genotypes	𝐴	𝐵	𝑃
(TA)6/(TA)5	0	0	—
(TA)5/(TA)7	1	0	—
(TA)6/(TA)6	30	0	1*
(TA)6/(TA)7	0	31	5.6×10^−10
(TA)7/(TA)7	0	11	3.2×10^−10
(TA)7/(TA)8	0	2	2×10^−3
(TA)8/(TA)8	0	1	0.119
Total	31	45

𝐴: total bilirubin level comprising between 15 and 34 𝜇mol/L.
𝐵: total bilirubin level comprising between 35 and 100 𝜇mol/L.
Usual value of bilirubin level: total bilirubin <17 𝜇mol/L.
1*: reference group.
𝑃: index of significance, each 𝑃<0.05 is considered as significant.