Research Article
Positive ALDH1A3 and Negative GPX3 Expressions Are Biomarkers for Poor Prognosis of Gallbladder Cancer
Table 1
The association of ALDH1A3 and GPX3 expressions with the clinicopathological characteristics of SC/ASC and AC.
| | Clinicopathological characteristics | Total number | ALDH1A3 | GPX3 | | Pos number (%) | | | | Pos number (%) | |
| | SC/ASC | | | | | | | | | Differentiation | | | | | | | | | Well | 16 | 5 (31.3) | 3.111 | 0.153 | 8 (50.0) | 2.001 | 0.352 | | Moderately | 24 | 7 (29.2) | 10 (41.7) | | Poorly | 6 | 4 (66.7) | 1 (16.7) | | Tumor mass size | | | | | | | | | ≤3 cm | 20 | 4 (20.0) | 3.409 | 0.065 | 10 (50.0) | 1.104 | 0.293 | | >3 cm | 26 | 12 (46.2) | 9 (34.6) | | TNM stage | | | | | | | | | I + II | 12 | 2 (16.7) | 7.953 | 0.019 | 8 (66.7) | 7.512 | 0.021 | | III | 20 | 5 (25.0) | 9 (45.0) | | IV | 14 | 9 (64.3) | 2 (14.3) | | Lymph metastasis | | | | | | | | | No | 17 | 2 (11.8) | 6.298 | 0.016 | 11 (64.7) | 6.091 | 0.019 | | Yes | 29 | 14 (48.3) | 8 (27.6) | | Invasion | | | | | | | | | No | 16 | 3 (18.8) | 2.780 | 0.091 | 10 (62.5) | 4.546 | 0.031 | | Yes | 30 | 13 (43.3) | 9 (30.0) | | AC | | | | | | | | | Differentiation | | | | | | | | | Well | 27 | 6 (22.2) | 11.840 | 0.003 | 18 (66.7) | 9.865 | 0.007 | | Moderately | 25 | 10 (40.0) | 13 (52.0) | | Poorly | 28 | 19 (67.9) | 7 (25.0) | | Tumor mass size | | | | | | | | | ≤3 cm | 50 | 15 (30.0) | 10.243 | 0.001 | 29 (58.0) | 5.895 | 0.015 | | >3 cm | 30 | 20 (66.7) | 9 (30.0) | | TNM stage | | | | | | | | | I + II | 21 | 6 (28.6) | 6.728 | 0.039 | 17 (81.0) | 16.357 | 0.000 | | III | 38 | 15 (39.5) | 17 (44.7) | | IV | 21 | 14 (66.7) | 4 (19.1) | | Lymph metastasis | | | | | | | | | No | 30 | 7 (23.3) | 8.130 | 0.004 | 20 (66.7) | 7.071 | 0.008 | | Yes | 50 | 28 (56.0) | 18 (36.0) | | Invasion | | | | | | | | | No | 31 | 9 (29.0) | 4.455 | 0.035 | 21 (67.7) | 8.316 | 0.003 | | Yes | 49 | 26 (53.1) | 17 (34.7) |
|
|
