Positive ALDH1A3 and Negative GPX3 Expressions Are Biomarkers for Poor Prognosis of Gallbladder Cancer

Table 3

Multivariate cox regression analysis of survival rate in SC/ASC and AC patients.

Groups	Factors	RC	SE	Wald	𝑃	RR	95% confidence interval
							Lower	Upper
SC/ASC
Differentiation	Well/moderately/poorly	.785	.350	5.030	0.025	2.192	1.104	4.354
Tumor mass size	≤3 cm/>3 cm	2.760	.790	12.206	0.000	15.800	3.359	74.321
TNM stage	I + II/III/IV	1.181	.449	6.918	0.009	3.258	1.351	7.854
Lymph metastasis	No/yes	1.107	.530	4.363	0.037	3.025	1.071	8.549
Invasion	No/yes	2.891	.849	11.595	0.001	18.011	3.411	95.111
Surgery	Radical/palliative/biopsy	1.203	.543	4.908	0.027	3.330	1.149	9.653
ALDH1A3	−/+	1.071	.521	4.226	0.040	2.918	1.051	8.102
GPX3	−/+	−1.333	.497	7.194	0.007	.264	.100	.698
AC
Differentiation	Well/moderately/poorly	1.055	.505	4.364	0.037	2.872	1.067	7.728
Tumor mass size	≤3 cm/>3 cm	.928	.455	4.160	0.041	2.529	1.037	6.171
TNM stage	I + II/III/IV	.997	.447	4.975	0.026	2.710	1.128	6.509
Lymph metastasis	No/yes	.947	.416	5.182	0.023	2.849	1.141	5.826
Invasion	No/yes	1.449	.514	7.947	0.005	4.259	1.555	11.663
Surgery	Radical/palliative/biopsy	1.911	.432	19.568	0.000	6.760	2.899	15.764
ALDH1A3	−/+	.942	.330	8.148	0.004	2.565	1.343	4.898
GPX3	−/+	−1.024	.367	7.785	0.005	0.359	.175	.737

RC: regression coefficients; SE: standard error; RR: relative risk.