Interleukin 18 as a Marker of Chronic Nephropathy in Children after Anticancer Treatment

Table 2

Concentrations of KIM-1, IL-18, and beta-2 microglobulin in patients after nephrectomy and radiotherapy of the abdominal cavity and of patients with/without signs of glomerulopathy and tubulopathy.

(a)

	Nephrectomy			Glomerulopathy			Tubulopathy
	Yes	No	𝑃	Yes	No	𝑃	Yes	No	𝑃
KIM-1 (ng/mL)	0.46 (0.36–0.66)	0.76 (0.40–1.20)	0.0321	0.51 (0.39–1.07)	0.66 (0.39–1.05)	0.8995	0.57 (0.36–1.03)	0.66 (0.39–1.07)	0.5720
IL-18 (pg/mL)	38.20 (14.62–82.08)	9.91 (6.04–30.09)	0.0064	8.41 (4.43–17.71)	17.93 (6.79–41.47)	0.1323	46.15 (12.37–82.08)	9.55 (5.39–26.06)	0.0001
B2m (mg/mL)	0.00 (0.00-0.00)	0.00 (0.00–0.05)	0.5337	0.00 (0.00-0.00)	0.00 (0.00–0.06)	0.6513	0.00 (0.00–0.40)	0.00 (0.00-0.00)	0.0500

(b)

	Radiotherapy of abdominal cavity
	Yes	No	𝑃
KIM-1 (ng/mL)	0.48 (0.43–0.84)	0.66 (0.39–1.07)	0.761321
IL-18 (pg/mL)	37.09 (20.31–115.52)	11.81 (6.20–38.20)	0.0010290
B2m (mg/mL)	0.45 (0.00–1.31)	0.00 (0.00-0.00)	0.019508