The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population
Table 3
Clinical characteristics and plasma levels of homocysteine, vitamin B12, and lipids in Alzheimer’s cases and controls.
Parameter
AD cases
Controls
Reference values
Number of patients
43
32
Gender ratio (male : female)
1 : 2.1
1 : 2.2
Age range, years
60–88
60–88
Mean age ± SD, years
69.2 ± 8.1
70.7 ± 8.8 y
Late onset (>65 y)a
25 (58.1%)
—
Family history, (+)a,b
2 (4.7%)
0 (0%)
Educational level (<8 y)a
39 (91%)
26 (81%)
Diabetes Mellitus, yesa
14 (32.6%)
7 (21.9%)
Hypertension, yesa
17 (39.5%)
18 (41.9%)
Anti-inflammatory drugs, yesa
5 (11.6%)
6 (18.8%)
Homocysteinec
18.4 ± 6.3d
13.0 ± 3.8
4–12.3 μmol/L
Vitamin B12c
310.1 ± 120.2e
400.2 ± 238.0
157–1059 pg/mL
Total cholesterolc
210.5 ± 30.1f
205 ± 40.5
150–200 mg/dL
LDLc
133.5 ± 32.5f
130.4 ± 20.8
100–129 mg/dL
HDLc
57.7 ± 18.4f
55.3 ± 15.5
>45 mg/dL
Triglyceridesc
113.0 ± 60.0f
125.4 ± 65.3
60–150 mg/dL
Abbreviations. AD: Alzheimer’s disease; SD: standard deviation.
aNumber of patients, with percentages in parentheses.
bFamily history was considered (+) if there was more than one case of Alzheimer’s disease in the same family and (−) if the case was sporadic.
cStudent's t-test. Values are mean ± SD.
dP < 0.0001, very highly significant difference.
eP = 0.0005, highly significant difference.
fP > 0.05, no significant difference.