Mutation of NPM1 and FLT3 Genes in Acute Myeloid Leukemia and Their Association with Clinical and Immunophenotypic Features
Table 2
Sequencing analysis of different patterns of NPM1 mutation in AML patients.
Sample ID
DNA sequence of exon 12 of NPM1 gene
Wild type
GATCTCTG —GCAG TGGAGGAAGTCTCTTTAAGAAAATAG
UH542
GATCTCTGTCTGGCAG TGGAGGAAGTCTCTTTAAGAAAATAG
UH545
GATCTCTGCATGGCAGTGGAGGAAGTCTCTTTAAGAAAATAG
UH533
GATCTCTG TTTGGCAG TGGAGGAAGTCTCTTTAAGAAAATAG
UH581
GATC CGCTTCTGGCAG TGGAGGAAGTCTCTTTAAGAAAATAG
UH591
GATC TATGTCTGGCAG TGGAGGAAGTCTCTTTAAGAAAATAG
UH595
GATCTCTGTCTGGCAG TGGAGGAAGTCTCTTTAAGAAAATAG
UH576
GATCTCTGTCTGGCAG TGGAGGAAGTCTCTTTAAGAAAATAG
UH567
GATCTCTGTGTGGCAG TGGAGGAAGTCTCTTTAAGAAAATAG
Sequence highlighted in bold color represents inserted nucleotides in NPM1 gene. TCTG is the most common 4 bp nucleotide insertion in exon 12 of NPM1 gene.