Investigation of Genetic Polymorphisms Related to the Outcome of Radiotherapy for Prostate Cancer Patients
Table 7
Association of the polymorphisms analysed with chronic skin, gastrointestinal, and urinary radiotoxicity*.
Chronic skin RTOG
Chronic gastrointestinal RTOG
Chronic urinary tract RTOG
Gene (refSNP)
Genotype
n (%)
HG
LG
OR
95% CI
P value
HG
LG
OR
95% CI
P value
HG
LG
OR
95% CI
P value
ATM
GG
35 (78)
0
35
2
33
8
27
(rs1801516)
10 (22)
1
9
0.089
0.003–2.372
0.222
0
10
1.567
0.069–35.323
1
2
8
1.185
0.208–6.740
1
TP53
GG
23 (51)
0
23
2
21
5
18
(rs1042522)
GC
16 (36)
1
15
0.220
0.008–5.756
0.410
0
16
3.837
0.172–85.533
0.503
2
14
1.944
0.327–11.563
0.678
CC
6 (13)
0
6
—
—
‡
0
6
1.512
0.064–35.678
1
3
3
0.278
0.042–1.825
0.305
TP53
CC
42 (95.5)
1
41
2
40
9
33
(rs1800371)
CT†
2 (4.5)
0
2
0.181
0.058–5.673
1
0
2
0.307
0.011–8.325
1
1
1
3.667
0.208–64.54
0.407
TP53
CC
40 (91)
0
40
2
38
7
33
(rs17883323)
4 (9)
1
3
0.029
0.001–0.848
0.091
0
4
0.584
0.024–14.199
1
3
1
0.071
0.006–0.784
0.032
TP53
CC
38 (88)
1
37
1
37
8
30
(rs35117667)
CT
2 (5)
0
2
0.200
0.006–6.288
1
1
1
0.027
0.001–0.819
0.099
0
2
1.393
0.061–31.901
1
TT
3 (7)
0
3
0.280
0.009–8.254
1
0
3
0.280
0.009–8.254
1
1
2
1.875
0.150–23.396
0.535
TP53
A1
37 (86)
1
36
2
35
8
29
(rs17878362)
A2
6 (14)
0
6
0.534
0.019–14.607
1
0
6
0.915
0.039–21.368
1
2
4
1.813
0.280–11.750
0.611
MDM2
TT
17 (38)
0
17
1
16
4
13
(rs2279744)
GT
25 (55)
1
24
0.467
0.018–12.152
1
1
24
1.500
0.087–25.753
1
6
19
0.974
0.229–4.148
1
GG
3 (7)
0
3
—
—
‡
0
3
0.636
0.212–19.124
1
0
3
2.333
0.100–54.460
1
Abbreviations: refSNP: reference SNP cluster report; RTOG: radiation therapy oncology group; HG: high grade RTOG; LG: low grade RTOG; OR: odds ratio; CI: confidence interval. To make calculations of Fishers exact test possible, when one value is zero, 0.5 was added to the value. For chronic analyses, it was considered patients with followup higher than 24 months. No carriers of an AA homozygous genotype were found. No carriers of a TT homozygous genotype were found. No patient high grade for the genotypes analysed.
