EphB4 Tyrosine Kinase Stimulation Inhibits Growth of MDA-MB-231 Breast Cancer Cells in a Dose and Time Dependent Manner
Figure 3
Formation of tubular network by MDA-MB-231 cells was tested on matrigel in presence and absence of ephrinB2-Fc. Cells were treated with (a) PBS, (b) 3 μg/mL ephrinB2-Fc and (c) 10 μg/mL ephrinB2-Fc. Treatment with ephrinB2-Fc was expected to totally abrogate tubular formation and form aggregated colonies, yet it was surprisingly observed that tubular formation was not inhibited by ephrinB2-Fc treatment compared to PBS. Figures were inspected at 100x magnification and scale bars represent 20 μm.
