Nuclear Expression of Snail Is an Independent Negative Prognostic Factor in Human Breast Cancer

Table 5

Multivariate analysis for the effect of clinicopathologic parameters and Snail expression on overall survival.

Clinicopathologic parameter	Hazard ratio (95% CI)	𝑃 value
Age (per 1 year )	1.037 (1.029–1.046)	<0.0001
Tumor stage
pT1 (reference)	1
pT2	1.392 (1.042–1.859)	0.0251
pT3	1.620 (1.047–2.508)	0.0303
pT4	1.619 (1.103–2.377)	0.0140
Lymph node involvement
pN1 (reference)	1
pN1	1.446 (1.147–1.822)	0.0018
pN2	2.603 (1.852–3.658)	<0.0001
Tumor grade
BRE grade 1 (reference)	1
2	1.593 (1.161–2.186)	0.0039
3	2.123 (1.510–2.986)	<0.0001
Snail expression, all cases
Snail positive	1.930 (1.476–2.524)	<0.0001
Snail expression, by intrinsic subtype
Luminal A (reference)	1
Luminal B (HER2^−)	1.012 (0.721–1.414)	0.9458
Luminal B (HER2^+)	1.206 (0.788–1.844)	0.3884
Her2	0.999 (0.618–1.614)	0.9958
Basal-like	1.258 (0.819–1.934)	0.2951