Combined Analysis of Serum Alpha-Fetoprotein and MAGE-A3-Specific Cytotoxic T Lymphocytes in Peripheral Blood for Diagnosis of Hepatocellular Carcinoma

Table 1

Demographic features and clinicopathologic characteristics of 85 HLA-A2 positive hepatocellular cancer patients and their correlation with the frequency of MAGE-A3⁺ CTL.

Variables	Frequency of MAGE-A3^+ CTL
	≥0.67%	<0.67%	𝑃^∗
Gender
Male	44	26	0.781
Female	10	5
Age (years)
66–85	14	8	0.413
46–65	29	20
28–45	11	3
AFP (ng/mL)
<20	20	18	0.268
20–200	11	4
>200	19	9
Tumor size
≥5 cm	23	20	0.057
<5 cm	24	8
Tumor number
Single	45	28	0.373
Multiple	9	3
HBsAg
Positive	36	24	0.295
Negative	18	7
Child-Pugh class
A	40	26	0.443
B	13	4
C	1	1
TNM stage
I/II	43	21	0.221
III/IV	11	10
Histological differentiation
Well/moderately	40	26	0.094
Low	14	3

∗Chi-square test and Fisher’s exact test.