Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis

Table 3

Salivary mediator levels at baseline, peak of induction (day 21), and at resolution (day 35) of experimental gingivitis.

	Baseline	Day 21	Day 35	𝐹 statistic	𝑃 value
IL-1𝛽 (pg/mL)	109.45 (32.13)	116.64 (44.35)	31.74 (11.79)	(2, 10) = 2.95	0.099
IL-2 (pg/mL)	7.61 (3.10)	20.93 (15.74)	16.17 (16.17)	(1.04, 5.19) = 0.44	0.543*
IL-4 (pg/mL)	0.43 (0.32)	1.70 (1.26)	0.68 (0.68)	(1.12, 5.62) = 0.98	0.375*
IL-5 (pg/mL)	1.97 (1.97)	4.39 (3.63)	1.20 (1.20)	(2, 10) = 0.56	0.587
IL-6 (pg/mL)	103.77 (43.00)	120.10 (45.46)	73.06 (31.41)	(2, 10) = 0.95	0.418
IL-10 (pg/mL)	0 (0)	5.84 (5.49)	3.13 (3.13)	(1.00, 5.01) = 1.13	0.337*
IL-12(p70) (pg/mL)	0.24 (0.24)	1.81 (1.55)	0.94 (0.94)	(1.06, 5.28) = 0.96	0.377*
IL-13 (pg/mL)	0.10 (0.10)	3.79 (3.52)	2.89 (2.89)	(1.01, 5.03) = 1.04	0.356*
IFN-𝛾 (pg/mL)	6.57 (2.39)	11.41 (5.10)	3.43 (2.05)	(2, 10) = 1.50	0.269
TNF-𝛼 (pg/mL)	3.63 (1.10)	4.81 (1.22)	1.54 (0.60)	(2, 10) = 2.48	0.133
sICAM-1 (ng/mL)	20.46 (7.90)	8.63 (5.65)	4.97 (4.97)	(2, 14) = 2.46	0.122
CRP (ng/mL)	6.76 (6.76)	0 (0)	6.76 (6.76)	(2, 14) = 0.48	0.127

Mediator levels are expressed as mean (SE).
*Greenhouse-Geisser correction for nonsphericity.