Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis

Table 4

Plasma mediator levels at baseline, peak of induction (day 21), and at resolution (day 35) of experimental gingivitis.

	Baseline	Day 21	Day 35	𝐹 statistic	𝑃 value
IL-1𝛽 (pg/mL)	0 (0)	0 (0)	0 (0)	—	—
IL-2 (pg/mL)	0 (0)	7.21 (5.64)	0 (0)	(2, 14) = 1.64	0.229
IL-4 (pg/mL)	0.15 (0.15)	0.28 (0.28)	0.42 (0.31)	(1.13, 7.90) = 0.44	0.549*
IL-5 (pg/mL)	40.44 (14.67)	26.16 (8.43)	44.39 (19.44)	(2, 14) = 1.50	0.258
IL-6 (pg/mL)	3.00 (1.50)	4.10 (2.50)	7.11 (5.66)	(1.11, 7.75) = 0.46	0.539*
IL-10 (pg/mL)	4.20 (3.03)	2.30 (1.60)	3.78 (2.98)	(2, 14) = 0.81	0.466
IL-12(p70) (pg/mL)	1.37 (1.05)	1.52 (0.81)	1.80 (1.19)	(2, 14) = 0.35	0.712
IL-13 (pg/mL)	0.55 (0.55)	0.12 (0.12)	0.55 (0.55)	(2, 14) = 1.00	0.393
IFN-𝛾 (pg/mL)	0.44 (0.24)	0.44 (0.33)	0.77 (0.77)	(1.18, 8.27) = 0.24	0.674*
TNF-𝛼 (pg/mL)	0 (0)	0 (0)	0 (0)	—	—
sICAM-1 (ng/mL)	85.73 (9.17)	220.20 (19.91)	229.69 (10.35)	(2, 14) = 31.95	<0.001
CRP (ng/mL)	1456.75 (652.23)	873.95 (355.55)	1269.01 (729.10)	(1.13, 7.94) = 1.43	0.273*

Mediator levels are expressed as mean (SE).
*Greenhouse-Geisser correction for nonsphericity.